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GqPCR-stimulated dephosphorylation of AKT is induced by an IGBP1-mediated PP2A switch

BACKGROUND: G protein-coupled receptors (GPCRs) usually regulate cellular processes via activation of intracellular signaling pathways. However, we have previously shown that in several cell lines, GqPCRs induce immediate inactivation of the AKT pathway, which leads to JNK-dependent apoptosis. This...

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Detalles Bibliográficos
Autores principales:	Nadel, Guy, Yao, Zhong, Wainstein, Ehud, Cohen, Izel, Ben-Ami, Ido, Schajnovitz, Amir, Maik-Rachline, Galia, Naor, Zvi, Horwitz, Benjamin A., Seger, Rony
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742922/ https://www.ncbi.nlm.nih.gov/pubmed/34998390 http://dx.doi.org/10.1186/s12964-021-00805-z

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