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Challenges in treatment of a patient suffering from neuroendocrine tumor G1 of the hilar bile duct: a case report

BACKGROUND: Neuroendocrine tumors (NETs) arise from neuroendocrine cells and are extremely rare in the biliary tract. Currently, there are no guidelines for the diagnosis and treatment of biliary NETs. We presented a case with NETs G1 of the hilar bile duct and the challenges for her treatment. CASE...

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Autores principales: Zhang, Biao, Li, Shuang, Sun, Zhen, Chen, Xu, Qi, Bing, Zhang, Qingkai, Zhang, Guixin, Shang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742925/
https://www.ncbi.nlm.nih.gov/pubmed/34998372
http://dx.doi.org/10.1186/s12876-021-02019-6
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author Zhang, Biao
Li, Shuang
Sun, Zhen
Chen, Xu
Qi, Bing
Zhang, Qingkai
Zhang, Guixin
Shang, Dong
author_facet Zhang, Biao
Li, Shuang
Sun, Zhen
Chen, Xu
Qi, Bing
Zhang, Qingkai
Zhang, Guixin
Shang, Dong
author_sort Zhang, Biao
collection PubMed
description BACKGROUND: Neuroendocrine tumors (NETs) arise from neuroendocrine cells and are extremely rare in the biliary tract. Currently, there are no guidelines for the diagnosis and treatment of biliary NETs. We presented a case with NETs G1 of the hilar bile duct and the challenges for her treatment. CASE PRESENTATION: A 24-year-old woman was presented to our department with painless jaundice and pruritus, and the preoperative diagnosis was Bismuth type II hilar cholangiocarcinoma. She underwent Roux-en-Y hepaticojejunostomy with excision of the extrahepatic biliary tree and radical lymphadenectomy. Unexpectedly, postoperative pathological and immunohistochemical examination indicated a perihilar bile duct NETs G1 with the microscopic invasion of the resected right hepatic duct. Then the patient received 3 cycles of adjuvant chemotherapy (Gemcitabine and tegafur-gimeracil-oteracil potassium capsule). At present, this patient has been following up for 24 months without recurrence or disease progression. CONCLUSION: We know little of biliary NETs because of its rarity. There are currently no guidelines for the diagnosis and treatment of biliary NETs. We reported a case of perihilar bile duct NETs G1 with R1 resection, as far as we know this is the first report. More information about biliary NETs should be registered.
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spelling pubmed-87429252022-01-10 Challenges in treatment of a patient suffering from neuroendocrine tumor G1 of the hilar bile duct: a case report Zhang, Biao Li, Shuang Sun, Zhen Chen, Xu Qi, Bing Zhang, Qingkai Zhang, Guixin Shang, Dong BMC Gastroenterol Case Report BACKGROUND: Neuroendocrine tumors (NETs) arise from neuroendocrine cells and are extremely rare in the biliary tract. Currently, there are no guidelines for the diagnosis and treatment of biliary NETs. We presented a case with NETs G1 of the hilar bile duct and the challenges for her treatment. CASE PRESENTATION: A 24-year-old woman was presented to our department with painless jaundice and pruritus, and the preoperative diagnosis was Bismuth type II hilar cholangiocarcinoma. She underwent Roux-en-Y hepaticojejunostomy with excision of the extrahepatic biliary tree and radical lymphadenectomy. Unexpectedly, postoperative pathological and immunohistochemical examination indicated a perihilar bile duct NETs G1 with the microscopic invasion of the resected right hepatic duct. Then the patient received 3 cycles of adjuvant chemotherapy (Gemcitabine and tegafur-gimeracil-oteracil potassium capsule). At present, this patient has been following up for 24 months without recurrence or disease progression. CONCLUSION: We know little of biliary NETs because of its rarity. There are currently no guidelines for the diagnosis and treatment of biliary NETs. We reported a case of perihilar bile duct NETs G1 with R1 resection, as far as we know this is the first report. More information about biliary NETs should be registered. BioMed Central 2022-01-08 /pmc/articles/PMC8742925/ /pubmed/34998372 http://dx.doi.org/10.1186/s12876-021-02019-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Zhang, Biao
Li, Shuang
Sun, Zhen
Chen, Xu
Qi, Bing
Zhang, Qingkai
Zhang, Guixin
Shang, Dong
Challenges in treatment of a patient suffering from neuroendocrine tumor G1 of the hilar bile duct: a case report
title Challenges in treatment of a patient suffering from neuroendocrine tumor G1 of the hilar bile duct: a case report
title_full Challenges in treatment of a patient suffering from neuroendocrine tumor G1 of the hilar bile duct: a case report
title_fullStr Challenges in treatment of a patient suffering from neuroendocrine tumor G1 of the hilar bile duct: a case report
title_full_unstemmed Challenges in treatment of a patient suffering from neuroendocrine tumor G1 of the hilar bile duct: a case report
title_short Challenges in treatment of a patient suffering from neuroendocrine tumor G1 of the hilar bile duct: a case report
title_sort challenges in treatment of a patient suffering from neuroendocrine tumor g1 of the hilar bile duct: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742925/
https://www.ncbi.nlm.nih.gov/pubmed/34998372
http://dx.doi.org/10.1186/s12876-021-02019-6
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