Research progress of the application of mesenchymal stem cells in chronic inflammatory systemic diseases

Chronic inflammatory systemic diseases are the result of the body's immune imbalance, with a long course and recurring episodes. Immunosuppressants are the main treatment, but not all patients respond well to it. Being capable of both self-renewal and differentiation into multiple tissue cells...

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Autores principales: Huang, Fangfang, Thokerunga, Erick, He, Fajian, Zhu, Xinyu, Wang, Zi, Tu, Jiancheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742935/
https://www.ncbi.nlm.nih.gov/pubmed/34998430
http://dx.doi.org/10.1186/s13287-021-02613-1
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author Huang, Fangfang
Thokerunga, Erick
He, Fajian
Zhu, Xinyu
Wang, Zi
Tu, Jiancheng
author_facet Huang, Fangfang
Thokerunga, Erick
He, Fajian
Zhu, Xinyu
Wang, Zi
Tu, Jiancheng
author_sort Huang, Fangfang
collection PubMed
description Chronic inflammatory systemic diseases are the result of the body's immune imbalance, with a long course and recurring episodes. Immunosuppressants are the main treatment, but not all patients respond well to it. Being capable of both self-renewal and differentiation into multiple tissue cells and low immunogenicity, mesenchymal stem cell is a promising treatment for chronic inflammatory systemic diseases. In this article, we describe the research progress and clinical application of mesenchymal stem cells in chronic inflammatory systemic diseases and look for influencing factors and biomarkers that can predict the outcome of patient with mesenchymal stem cell transplantation.
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spelling pubmed-87429352022-01-10 Research progress of the application of mesenchymal stem cells in chronic inflammatory systemic diseases Huang, Fangfang Thokerunga, Erick He, Fajian Zhu, Xinyu Wang, Zi Tu, Jiancheng Stem Cell Res Ther Review Chronic inflammatory systemic diseases are the result of the body's immune imbalance, with a long course and recurring episodes. Immunosuppressants are the main treatment, but not all patients respond well to it. Being capable of both self-renewal and differentiation into multiple tissue cells and low immunogenicity, mesenchymal stem cell is a promising treatment for chronic inflammatory systemic diseases. In this article, we describe the research progress and clinical application of mesenchymal stem cells in chronic inflammatory systemic diseases and look for influencing factors and biomarkers that can predict the outcome of patient with mesenchymal stem cell transplantation. BioMed Central 2022-01-08 /pmc/articles/PMC8742935/ /pubmed/34998430 http://dx.doi.org/10.1186/s13287-021-02613-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Huang, Fangfang
Thokerunga, Erick
He, Fajian
Zhu, Xinyu
Wang, Zi
Tu, Jiancheng
Research progress of the application of mesenchymal stem cells in chronic inflammatory systemic diseases
title Research progress of the application of mesenchymal stem cells in chronic inflammatory systemic diseases
title_full Research progress of the application of mesenchymal stem cells in chronic inflammatory systemic diseases
title_fullStr Research progress of the application of mesenchymal stem cells in chronic inflammatory systemic diseases
title_full_unstemmed Research progress of the application of mesenchymal stem cells in chronic inflammatory systemic diseases
title_short Research progress of the application of mesenchymal stem cells in chronic inflammatory systemic diseases
title_sort research progress of the application of mesenchymal stem cells in chronic inflammatory systemic diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742935/
https://www.ncbi.nlm.nih.gov/pubmed/34998430
http://dx.doi.org/10.1186/s13287-021-02613-1
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