Amino acid substitutions in the H5N1 avian influenza haemagglutinin alter pH of fusion and receptor binding to promote a highly pathogenic phenotype in chickens

Highly pathogenic H5N1 avian influenza viruses cause devastating outbreaks in farmed poultry with serious consequences for animal welfare and economic losses. Zoonotic infection of humans through close contact with H5N1 infected birds is often severe and fatal. England experienced an outbreak of H5N...

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Detalles Bibliográficos
Autores principales: Sealy, Joshua E., Howard, Wendy A., Molesti, Eleonora, Iqbal, Munir, Temperton, Nigel J., Banks, Jill, Slomka, Marek J., Barclay, Wendy S., Long, Jason S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2021
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742987/
https://www.ncbi.nlm.nih.gov/pubmed/34726594
http://dx.doi.org/10.1099/jgv.0.001672

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