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Mechanisms of the Effects of Short-Term Inhalations of Xe and O(2) Gas Mixture in the Rehabilitation of Post-COVID Ventilation Failure

The article presents a theoretical rationale and a clinical case of relief of post-COVID ventilation failure by inhalation of Xe and O(2) gas mixture. Pneumonitis of coronavirus etiology transforms saturated phospholipids of surfactant into a solid-ordered phase, which disrupts surface tension, alve...

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Detalles Bibliográficos
Autores principales: Udut, V. V., Naumov, S. A., Udut, E. V., Naumov, S. S., Evtushenko, D. N., Chumakova, O. N., Zyuz’kov, G. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743161/
https://www.ncbi.nlm.nih.gov/pubmed/35001305
http://dx.doi.org/10.1007/s10517-022-05393-7
Descripción
Sumario:The article presents a theoretical rationale and a clinical case of relief of post-COVID ventilation failure by inhalation of Xe and O(2) gas mixture. Pneumonitis of coronavirus etiology transforms saturated phospholipids of surfactant into a solid-ordered phase, which disrupts surface tension, alveolar pneumatization, and alveolar-capillary gas exchange. Using molecular modeling (B3LYP/lanl2dz; GAUSSIAN09), we demonstrated that Xe atom due to the van der Waals dispersion interaction increases the distance between the phospholipid acyl chains providing a phase transition from the solid-ordered to liquid phase and restored the surface-active monolayer surfactant film. A clinical case confirmed that short-term inhalations of the Xe and O(2) gas mixture relieved manifestations of ventilation insufficiency and increased SpO(2) and pneumatization of the terminal parts of the lungs.