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Medical history risk factors in primary progressive multiple sclerosis: A case-control study
Background: The association between medical history and primary progressive multiple sclerosis (PPMS) development has not been well documented in the pertinent literature. The possible association between 23 medical diseases and PPMS occurrence was assessed in the present study. Methods: In order to...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743179/ http://dx.doi.org/10.18502/cjn.v20i2.6744 |
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author | Maroufi, Hossein Moghadasi, Abdorreza Naser Rezaei-Aliabadi, Hossein Sahraian, Mohammad Ali Eskandarieh, Sharareh |
author_facet | Maroufi, Hossein Moghadasi, Abdorreza Naser Rezaei-Aliabadi, Hossein Sahraian, Mohammad Ali Eskandarieh, Sharareh |
author_sort | Maroufi, Hossein |
collection | PubMed |
description | Background: The association between medical history and primary progressive multiple sclerosis (PPMS) development has not been well documented in the pertinent literature. The possible association between 23 medical diseases and PPMS occurrence was assessed in the present study. Methods: In order to figure out the possible association between several medical histories and PPMS occurrence, the present population-based case-control study examined 143 PPMS cases in Tehran, Iran, from 2019 to 2020. Diagnosis of PPMS was confirmed by neurologists based on the 2017 McDonald criteria. Sex-matched healthy controls (n = 143) were selected using the random-digit dialing (RDD) technique. Face-to-face and telephone interviews were conducted for gathering the data. The conditional logistic regression model was used to calculate adjusted and unadjusted odds ratio (OR) at a 95% confidence interval (CI). Results: A significant association was found between PPMS development and diseases like depression (OR = 3.12, 95% CI: 1.49-6.53), migraine (OR = 0.19, 95% CI: 0.05-0.67), infectious mononucleosis (OR = 13.16, 95% CI: 2.74-63.17), hypothyroidism (OR = 3.20, 95% CI: 1.23-8.30), and kidney failure (OR = 3.76, 95% CI: 1.41-9.99). Conclusion: Lifetime history of depression, infectious mononucleosis, hypothyroidism, and kidney failure might increase the risk of PPMS development, while individuals with positive history of migraine disease are at lower risk for developing PPMS. |
format | Online Article Text |
id | pubmed-8743179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-87431792022-01-25 Medical history risk factors in primary progressive multiple sclerosis: A case-control study Maroufi, Hossein Moghadasi, Abdorreza Naser Rezaei-Aliabadi, Hossein Sahraian, Mohammad Ali Eskandarieh, Sharareh Curr J Neurol Original Article Background: The association between medical history and primary progressive multiple sclerosis (PPMS) development has not been well documented in the pertinent literature. The possible association between 23 medical diseases and PPMS occurrence was assessed in the present study. Methods: In order to figure out the possible association between several medical histories and PPMS occurrence, the present population-based case-control study examined 143 PPMS cases in Tehran, Iran, from 2019 to 2020. Diagnosis of PPMS was confirmed by neurologists based on the 2017 McDonald criteria. Sex-matched healthy controls (n = 143) were selected using the random-digit dialing (RDD) technique. Face-to-face and telephone interviews were conducted for gathering the data. The conditional logistic regression model was used to calculate adjusted and unadjusted odds ratio (OR) at a 95% confidence interval (CI). Results: A significant association was found between PPMS development and diseases like depression (OR = 3.12, 95% CI: 1.49-6.53), migraine (OR = 0.19, 95% CI: 0.05-0.67), infectious mononucleosis (OR = 13.16, 95% CI: 2.74-63.17), hypothyroidism (OR = 3.20, 95% CI: 1.23-8.30), and kidney failure (OR = 3.76, 95% CI: 1.41-9.99). Conclusion: Lifetime history of depression, infectious mononucleosis, hypothyroidism, and kidney failure might increase the risk of PPMS development, while individuals with positive history of migraine disease are at lower risk for developing PPMS. Tehran University of Medical Sciences 2021-04-04 /pmc/articles/PMC8743179/ http://dx.doi.org/10.18502/cjn.v20i2.6744 Text en Copyright © 2021 Iranian Neurological Association, and Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited. |
spellingShingle | Original Article Maroufi, Hossein Moghadasi, Abdorreza Naser Rezaei-Aliabadi, Hossein Sahraian, Mohammad Ali Eskandarieh, Sharareh Medical history risk factors in primary progressive multiple sclerosis: A case-control study |
title | Medical history risk factors in primary progressive multiple sclerosis: A case-control study |
title_full | Medical history risk factors in primary progressive multiple sclerosis: A case-control study |
title_fullStr | Medical history risk factors in primary progressive multiple sclerosis: A case-control study |
title_full_unstemmed | Medical history risk factors in primary progressive multiple sclerosis: A case-control study |
title_short | Medical history risk factors in primary progressive multiple sclerosis: A case-control study |
title_sort | medical history risk factors in primary progressive multiple sclerosis: a case-control study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743179/ http://dx.doi.org/10.18502/cjn.v20i2.6744 |
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