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Acute and early developmental outcomes of children with Duarte galactosemia

A recent study demonstrated that children with Duarte galactosemia (DG) do not show increased prevalence of detectable developmental complications when 6–12 years old. However, that study left unanswered whether infants with DG might be at increased risk for acute problems when drinking milk or whet...

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Autores principales: Fridovich‐Keil, Judith L., Carlock, Grace, Patel, Sneh, Potter, Nancy L., Coles, Claire D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743335/
https://www.ncbi.nlm.nih.gov/pubmed/35028275
http://dx.doi.org/10.1002/jmd2.12267
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author Fridovich‐Keil, Judith L.
Carlock, Grace
Patel, Sneh
Potter, Nancy L.
Coles, Claire D.
author_facet Fridovich‐Keil, Judith L.
Carlock, Grace
Patel, Sneh
Potter, Nancy L.
Coles, Claire D.
author_sort Fridovich‐Keil, Judith L.
collection PubMed
description A recent study demonstrated that children with Duarte galactosemia (DG) do not show increased prevalence of detectable developmental complications when 6–12 years old. However, that study left unanswered whether infants with DG might be at increased risk for acute problems when drinking milk or whether children with DG younger than 6 years might show increased prevalence of perhaps transient developmental challenges. Here, we have addressed both of these questions by analyzing parent/guardian‐reported data collected retrospectively for 350 children, 206 with DG and 144 unaffected siblings from the same families. The variables analyzed included whether each child had experienced (1) acute complications in infancy, (2) early intervention services when <3 years old, and/or (3) special educational services when 3–5 years old. For each case–control comparison, or case‐by‐diet comparison, we used logistic regression that included the following potential covariates: age, sex, race, family income, and parent education, as appropriate. We found that none of the three outcome variables tested showed significant differences between cases and controls, or among cases as a function of galactose exposure in infancy. To the limits of our study, we therefore conclude that regardless of whether a child with DG drinks milk or low‐galactose formula as an infant, they are not at increased risk for acute complications or early childhood developmental challenges that require intervention.
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spelling pubmed-87433352022-01-12 Acute and early developmental outcomes of children with Duarte galactosemia Fridovich‐Keil, Judith L. Carlock, Grace Patel, Sneh Potter, Nancy L. Coles, Claire D. JIMD Rep Research Reports A recent study demonstrated that children with Duarte galactosemia (DG) do not show increased prevalence of detectable developmental complications when 6–12 years old. However, that study left unanswered whether infants with DG might be at increased risk for acute problems when drinking milk or whether children with DG younger than 6 years might show increased prevalence of perhaps transient developmental challenges. Here, we have addressed both of these questions by analyzing parent/guardian‐reported data collected retrospectively for 350 children, 206 with DG and 144 unaffected siblings from the same families. The variables analyzed included whether each child had experienced (1) acute complications in infancy, (2) early intervention services when <3 years old, and/or (3) special educational services when 3–5 years old. For each case–control comparison, or case‐by‐diet comparison, we used logistic regression that included the following potential covariates: age, sex, race, family income, and parent education, as appropriate. We found that none of the three outcome variables tested showed significant differences between cases and controls, or among cases as a function of galactose exposure in infancy. To the limits of our study, we therefore conclude that regardless of whether a child with DG drinks milk or low‐galactose formula as an infant, they are not at increased risk for acute complications or early childhood developmental challenges that require intervention. John Wiley & Sons, Inc. 2021-12-16 /pmc/articles/PMC8743335/ /pubmed/35028275 http://dx.doi.org/10.1002/jmd2.12267 Text en © 2021 The Authors. JIMD Reports published by John Wiley & Sons Ltd on behalf of SSIEM. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Reports
Fridovich‐Keil, Judith L.
Carlock, Grace
Patel, Sneh
Potter, Nancy L.
Coles, Claire D.
Acute and early developmental outcomes of children with Duarte galactosemia
title Acute and early developmental outcomes of children with Duarte galactosemia
title_full Acute and early developmental outcomes of children with Duarte galactosemia
title_fullStr Acute and early developmental outcomes of children with Duarte galactosemia
title_full_unstemmed Acute and early developmental outcomes of children with Duarte galactosemia
title_short Acute and early developmental outcomes of children with Duarte galactosemia
title_sort acute and early developmental outcomes of children with duarte galactosemia
topic Research Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743335/
https://www.ncbi.nlm.nih.gov/pubmed/35028275
http://dx.doi.org/10.1002/jmd2.12267
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