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Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine
An orally active vaccine capable of boosting SARS-CoV-2 immune responses in previously infected or vaccinated individuals would help efforts to achieve and sustain herd immunity. Unlike mRNA-loaded lipid nanoparticles and recombinant replication-defective adenoviruses, replicating vesicular stomatit...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Published by Elsevier Ltd.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743387/ https://www.ncbi.nlm.nih.gov/pubmed/35282925 http://dx.doi.org/10.1016/j.vaccine.2021.12.063 |
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| author | Peng, Kah-Whye Carey, Timothy Lech, Patrycja Vandergaast, Rianna Muñoz-Alía, Miguel Á. Packiriswamy, Nandakumar Gnanadurai, Clement Krotova, Karina Tesfay, Mulu Ziegler, Christopher Haselton, Michelle Sevola, Kara Lathrum, Chase Reiter, Samantha Narjari, Riya Balakrishnan, Baskar Suksanpaisan, Lukkana Sakuma, Toshie Recker, Jordan Zhang, Lianwen Waniger, Scott Russell, Luke Petro, Christopher D. Kyratsous, Christos A. Baum, Alina Janecek, Jody L. Lee, Rachael M. Ramachandran, Sabarinathan Graham, Melanie L. Russell, Stephen J. |
| author_facet | Peng, Kah-Whye Carey, Timothy Lech, Patrycja Vandergaast, Rianna Muñoz-Alía, Miguel Á. Packiriswamy, Nandakumar Gnanadurai, Clement Krotova, Karina Tesfay, Mulu Ziegler, Christopher Haselton, Michelle Sevola, Kara Lathrum, Chase Reiter, Samantha Narjari, Riya Balakrishnan, Baskar Suksanpaisan, Lukkana Sakuma, Toshie Recker, Jordan Zhang, Lianwen Waniger, Scott Russell, Luke Petro, Christopher D. Kyratsous, Christos A. Baum, Alina Janecek, Jody L. Lee, Rachael M. Ramachandran, Sabarinathan Graham, Melanie L. Russell, Stephen J. |
| author_sort | Peng, Kah-Whye |
| collection | PubMed |
| description | An orally active vaccine capable of boosting SARS-CoV-2 immune responses in previously infected or vaccinated individuals would help efforts to achieve and sustain herd immunity. Unlike mRNA-loaded lipid nanoparticles and recombinant replication-defective adenoviruses, replicating vesicular stomatitis viruses with SARS-CoV-2 spike glycoproteins (VSV-SARS2) were poorly immunogenic after intramuscular administration in clinical trials. Here, by G protein trans-complementation, we generated VSV-SARS2(+G) virions with expanded target cell tropism. Compared to parental VSV-SARS2, G-supplemented viruses were orally active in virus-naive and vaccine-primed cynomolgus macaques, powerfully boosting SARS-CoV-2 neutralizing antibody titers. Clinical testing of this oral VSV-SARS2(+G) vaccine is planned. |
| format | Online Article Text |
| id | pubmed-8743387 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Published by Elsevier Ltd. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-87433872022-01-10 Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine Peng, Kah-Whye Carey, Timothy Lech, Patrycja Vandergaast, Rianna Muñoz-Alía, Miguel Á. Packiriswamy, Nandakumar Gnanadurai, Clement Krotova, Karina Tesfay, Mulu Ziegler, Christopher Haselton, Michelle Sevola, Kara Lathrum, Chase Reiter, Samantha Narjari, Riya Balakrishnan, Baskar Suksanpaisan, Lukkana Sakuma, Toshie Recker, Jordan Zhang, Lianwen Waniger, Scott Russell, Luke Petro, Christopher D. Kyratsous, Christos A. Baum, Alina Janecek, Jody L. Lee, Rachael M. Ramachandran, Sabarinathan Graham, Melanie L. Russell, Stephen J. Vaccine Article An orally active vaccine capable of boosting SARS-CoV-2 immune responses in previously infected or vaccinated individuals would help efforts to achieve and sustain herd immunity. Unlike mRNA-loaded lipid nanoparticles and recombinant replication-defective adenoviruses, replicating vesicular stomatitis viruses with SARS-CoV-2 spike glycoproteins (VSV-SARS2) were poorly immunogenic after intramuscular administration in clinical trials. Here, by G protein trans-complementation, we generated VSV-SARS2(+G) virions with expanded target cell tropism. Compared to parental VSV-SARS2, G-supplemented viruses were orally active in virus-naive and vaccine-primed cynomolgus macaques, powerfully boosting SARS-CoV-2 neutralizing antibody titers. Clinical testing of this oral VSV-SARS2(+G) vaccine is planned. Published by Elsevier Ltd. 2022-04-01 2022-01-10 /pmc/articles/PMC8743387/ /pubmed/35282925 http://dx.doi.org/10.1016/j.vaccine.2021.12.063 Text en © 2021 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Article Peng, Kah-Whye Carey, Timothy Lech, Patrycja Vandergaast, Rianna Muñoz-Alía, Miguel Á. Packiriswamy, Nandakumar Gnanadurai, Clement Krotova, Karina Tesfay, Mulu Ziegler, Christopher Haselton, Michelle Sevola, Kara Lathrum, Chase Reiter, Samantha Narjari, Riya Balakrishnan, Baskar Suksanpaisan, Lukkana Sakuma, Toshie Recker, Jordan Zhang, Lianwen Waniger, Scott Russell, Luke Petro, Christopher D. Kyratsous, Christos A. Baum, Alina Janecek, Jody L. Lee, Rachael M. Ramachandran, Sabarinathan Graham, Melanie L. Russell, Stephen J. Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine |
| title | Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine |
| title_full | Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine |
| title_fullStr | Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine |
| title_full_unstemmed | Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine |
| title_short | Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine |
| title_sort | boosting of sars-cov-2 immunity in nonhuman primates using an oral rhabdoviral vaccine |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743387/ https://www.ncbi.nlm.nih.gov/pubmed/35282925 http://dx.doi.org/10.1016/j.vaccine.2021.12.063 |
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