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Comparison of outcomes in DeBakey type I versus DeBakey type II aortic dissection: a 17-year single center experience

BACKGROUND: It is controversial if the type or the size of aortic dissection is associated with the mortality in patients with acute aortic dissection (AAD) type I or type II according to DeBakey. Due to the pronounced aortic pathology in DeBakey type I compared to DeBakey type II, it is to be expec...

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Autores principales: Salehi Ravesh, Mona, Salem, Mohamed, Lutter, Georg, Friedrich, Christine, Walter, Veronika, Puehler, Thomas, Cremer, Jochen, Haneya, Assad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743420/
https://www.ncbi.nlm.nih.gov/pubmed/35070361
http://dx.doi.org/10.21037/jtd-21-809
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author Salehi Ravesh, Mona
Salem, Mohamed
Lutter, Georg
Friedrich, Christine
Walter, Veronika
Puehler, Thomas
Cremer, Jochen
Haneya, Assad
author_facet Salehi Ravesh, Mona
Salem, Mohamed
Lutter, Georg
Friedrich, Christine
Walter, Veronika
Puehler, Thomas
Cremer, Jochen
Haneya, Assad
author_sort Salehi Ravesh, Mona
collection PubMed
description BACKGROUND: It is controversial if the type or the size of aortic dissection is associated with the mortality in patients with acute aortic dissection (AAD) type I or type II according to DeBakey. Due to the pronounced aortic pathology in DeBakey type I compared to DeBakey type II, it is to be expected, that the DeBakey type I is associated with a significant higher morbidity and mortality. But we hypothesize that the current advances in surgical techniques, circulatory management, and postoperative care improve the clinical outcome of patients with DeBakey type I and II. The purpose of this study was to evaluate retrospectively the effect of these parameters on surgical outcome in patients with DeBakey type I and type II in a large cohort study. METHODS: From 2001 to 2019, 395 consecutive patients (34.2% female) underwent surgical aortic repair at our institution. Patients were retrospectively classified into 2 groups: patients with type 1 dissection (group 1: n=309, median age of 62.0 years) and patients with type 2 dissection (group 2: n=86, 67.5 years). Survival was estimated by Kaplan-Meier estimator. Risk factors were analyzed by logistic regression analysis. RESULTS: The patients in group 1 suffered significantly more often from coronary heart disease [43 (13.9%) vs. 20 (23.3%), P=0.036]. Otherwise, there were no significant differences between both groups concerning preoperative risk factors. The median surgical duration (279 vs. 263 min, P=0.026) and the circulatory arrest time (35 vs. 27 min, P<0.001) in group 1 were significantly higher. In a significantly higher number of patients in group 1, the aortic arch was completely replaced (18.4% vs. 1.2%, P<0.001) and a simultaneous coronary artery bypass grafting [18 (5.8%) vs. 11 (12.8%), P=0.028] was performed. The rate of re-thoracotomy [62 (20.1%) vs. 9 (10.5%), P=0.040], of postoperative delirium [66 (21.4%) vs. 9 (10.6%), P=0.024], and of tracheotomy [85 (27.5%) vs. 14 (16.3%), P=0.034] were significantly higher in group 1. Thirty-day mortality was 15.7% and did not differ significantly between both groups (P=0.867), as well as the long-term survival rates (P=0.956). CONCLUSIONS: Due to the pronounced aortic pathology in type I compared to type II, it is to be expected, that the type I is associated with a significant higher morbidity and mortality. DeBakey type I was an independent predictor for 30-day mortality in our study, however, based on our 17-year single center experience there was no difference between the long-term survival in both groups.
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spelling pubmed-87434202022-01-21 Comparison of outcomes in DeBakey type I versus DeBakey type II aortic dissection: a 17-year single center experience Salehi Ravesh, Mona Salem, Mohamed Lutter, Georg Friedrich, Christine Walter, Veronika Puehler, Thomas Cremer, Jochen Haneya, Assad J Thorac Dis Original Article BACKGROUND: It is controversial if the type or the size of aortic dissection is associated with the mortality in patients with acute aortic dissection (AAD) type I or type II according to DeBakey. Due to the pronounced aortic pathology in DeBakey type I compared to DeBakey type II, it is to be expected, that the DeBakey type I is associated with a significant higher morbidity and mortality. But we hypothesize that the current advances in surgical techniques, circulatory management, and postoperative care improve the clinical outcome of patients with DeBakey type I and II. The purpose of this study was to evaluate retrospectively the effect of these parameters on surgical outcome in patients with DeBakey type I and type II in a large cohort study. METHODS: From 2001 to 2019, 395 consecutive patients (34.2% female) underwent surgical aortic repair at our institution. Patients were retrospectively classified into 2 groups: patients with type 1 dissection (group 1: n=309, median age of 62.0 years) and patients with type 2 dissection (group 2: n=86, 67.5 years). Survival was estimated by Kaplan-Meier estimator. Risk factors were analyzed by logistic regression analysis. RESULTS: The patients in group 1 suffered significantly more often from coronary heart disease [43 (13.9%) vs. 20 (23.3%), P=0.036]. Otherwise, there were no significant differences between both groups concerning preoperative risk factors. The median surgical duration (279 vs. 263 min, P=0.026) and the circulatory arrest time (35 vs. 27 min, P<0.001) in group 1 were significantly higher. In a significantly higher number of patients in group 1, the aortic arch was completely replaced (18.4% vs. 1.2%, P<0.001) and a simultaneous coronary artery bypass grafting [18 (5.8%) vs. 11 (12.8%), P=0.028] was performed. The rate of re-thoracotomy [62 (20.1%) vs. 9 (10.5%), P=0.040], of postoperative delirium [66 (21.4%) vs. 9 (10.6%), P=0.024], and of tracheotomy [85 (27.5%) vs. 14 (16.3%), P=0.034] were significantly higher in group 1. Thirty-day mortality was 15.7% and did not differ significantly between both groups (P=0.867), as well as the long-term survival rates (P=0.956). CONCLUSIONS: Due to the pronounced aortic pathology in type I compared to type II, it is to be expected, that the type I is associated with a significant higher morbidity and mortality. DeBakey type I was an independent predictor for 30-day mortality in our study, however, based on our 17-year single center experience there was no difference between the long-term survival in both groups. AME Publishing Company 2021-12 /pmc/articles/PMC8743420/ /pubmed/35070361 http://dx.doi.org/10.21037/jtd-21-809 Text en 2021 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Salehi Ravesh, Mona
Salem, Mohamed
Lutter, Georg
Friedrich, Christine
Walter, Veronika
Puehler, Thomas
Cremer, Jochen
Haneya, Assad
Comparison of outcomes in DeBakey type I versus DeBakey type II aortic dissection: a 17-year single center experience
title Comparison of outcomes in DeBakey type I versus DeBakey type II aortic dissection: a 17-year single center experience
title_full Comparison of outcomes in DeBakey type I versus DeBakey type II aortic dissection: a 17-year single center experience
title_fullStr Comparison of outcomes in DeBakey type I versus DeBakey type II aortic dissection: a 17-year single center experience
title_full_unstemmed Comparison of outcomes in DeBakey type I versus DeBakey type II aortic dissection: a 17-year single center experience
title_short Comparison of outcomes in DeBakey type I versus DeBakey type II aortic dissection: a 17-year single center experience
title_sort comparison of outcomes in debakey type i versus debakey type ii aortic dissection: a 17-year single center experience
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743420/
https://www.ncbi.nlm.nih.gov/pubmed/35070361
http://dx.doi.org/10.21037/jtd-21-809
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