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A common TMPRSS2 variant has a protective effect against severe COVID-19

BACKGROUND: The human protein transmembrane protease serine type 2 (TMPRSS2) plays a key role in SARS-CoV-2 infection, as it is required to activate the virus’ spike protein, facilitating entry into target cells. We hypothesized that naturally-occurring TMPRSS2 human genetic variants affecting the s...

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Detalles Bibliográficos
Autores principales:	David, Alessia, Parkinson, Nicholas, Peacock, Thomas P, Pairo-Castineira, Erola, Khanna, Tarun, Cobat, Aurelie, Tenesa, Albert, Sancho-Shimizu, Vanessa, Casanova, Jean-Laurent, Abel, Laurent, Barclay, Wendy S., Baillie, J.Kenneth, Sternberg, Michael JE
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier-Masson SAS 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743599/ https://www.ncbi.nlm.nih.gov/pubmed/35104687 http://dx.doi.org/10.1016/j.retram.2022.103333

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