Case series of intravenous thrombolysis for acute ischemic stroke in confirmed COVID-19 patients: single-centre experience

BACKGROUND: Coronavirus disease 2019 (COVID-19) not only caused a large surge of respiratory infections, it also had a potential association with and increases the risk of stroke. The pandemic has certainly provided new challenges and opportunities in the management of acute ischemic stroke (AIS); h...

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Autores principales: Alwahdy, Ahmad Sulaiman, Margaretha, Ika Yulieta, Pramesti, Kenyo Sembodro, Hamro, Nailaufar, Yuzella, Viska, Nasution, Fitriani, Mappalilu, Arfan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743695/
https://www.ncbi.nlm.nih.gov/pubmed/35035211
http://dx.doi.org/10.1186/s41983-021-00434-w
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author Alwahdy, Ahmad Sulaiman
Margaretha, Ika Yulieta
Pramesti, Kenyo Sembodro
Hamro, Nailaufar
Yuzella, Viska
Nasution, Fitriani
Mappalilu, Arfan
author_facet Alwahdy, Ahmad Sulaiman
Margaretha, Ika Yulieta
Pramesti, Kenyo Sembodro
Hamro, Nailaufar
Yuzella, Viska
Nasution, Fitriani
Mappalilu, Arfan
author_sort Alwahdy, Ahmad Sulaiman
collection PubMed
description BACKGROUND: Coronavirus disease 2019 (COVID-19) not only caused a large surge of respiratory infections, it also had a potential association with and increases the risk of stroke. The pandemic has certainly provided new challenges and opportunities in the management of acute ischemic stroke (AIS); however, data regarding outcomes of intravenous tissue plasminogen activator (IV TPA) administration in stroke patients with COVID-19 remains limited. CASE PRESENTATION: Three AIS patients with confirmed COVID-19 treated using IV tPA. One case had excellent outcome, while the other cases showed unfavorable results. The risk–benefit ratio of IV TPA in COVID-19 remains unclear. CONCLUSION: In this article, we discuss the possible explanation behind these different outcomes. Although IV tPA could not cure COVID-19, we suggest that its administration should not be delayed in AIS patients with COVID-19.
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spelling pubmed-87436952022-01-10 Case series of intravenous thrombolysis for acute ischemic stroke in confirmed COVID-19 patients: single-centre experience Alwahdy, Ahmad Sulaiman Margaretha, Ika Yulieta Pramesti, Kenyo Sembodro Hamro, Nailaufar Yuzella, Viska Nasution, Fitriani Mappalilu, Arfan Egypt J Neurol Psychiatr Neurosurg Case Report BACKGROUND: Coronavirus disease 2019 (COVID-19) not only caused a large surge of respiratory infections, it also had a potential association with and increases the risk of stroke. The pandemic has certainly provided new challenges and opportunities in the management of acute ischemic stroke (AIS); however, data regarding outcomes of intravenous tissue plasminogen activator (IV TPA) administration in stroke patients with COVID-19 remains limited. CASE PRESENTATION: Three AIS patients with confirmed COVID-19 treated using IV tPA. One case had excellent outcome, while the other cases showed unfavorable results. The risk–benefit ratio of IV TPA in COVID-19 remains unclear. CONCLUSION: In this article, we discuss the possible explanation behind these different outcomes. Although IV tPA could not cure COVID-19, we suggest that its administration should not be delayed in AIS patients with COVID-19. Springer Berlin Heidelberg 2022-01-10 2022 /pmc/articles/PMC8743695/ /pubmed/35035211 http://dx.doi.org/10.1186/s41983-021-00434-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Report
Alwahdy, Ahmad Sulaiman
Margaretha, Ika Yulieta
Pramesti, Kenyo Sembodro
Hamro, Nailaufar
Yuzella, Viska
Nasution, Fitriani
Mappalilu, Arfan
Case series of intravenous thrombolysis for acute ischemic stroke in confirmed COVID-19 patients: single-centre experience
title Case series of intravenous thrombolysis for acute ischemic stroke in confirmed COVID-19 patients: single-centre experience
title_full Case series of intravenous thrombolysis for acute ischemic stroke in confirmed COVID-19 patients: single-centre experience
title_fullStr Case series of intravenous thrombolysis for acute ischemic stroke in confirmed COVID-19 patients: single-centre experience
title_full_unstemmed Case series of intravenous thrombolysis for acute ischemic stroke in confirmed COVID-19 patients: single-centre experience
title_short Case series of intravenous thrombolysis for acute ischemic stroke in confirmed COVID-19 patients: single-centre experience
title_sort case series of intravenous thrombolysis for acute ischemic stroke in confirmed covid-19 patients: single-centre experience
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743695/
https://www.ncbi.nlm.nih.gov/pubmed/35035211
http://dx.doi.org/10.1186/s41983-021-00434-w
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