Thrombospondin-1 aggravates colonic mucosal inflammatory injuries via promoting the differentiation of CD11c(+) macrophages with lysosomal activity limited in colitis

BACKGROUND: Increased CD11c(+) Mφ aggravates colonic mucosal injuries in ulcerative colitis (UC) with TSP1 protein increased. The thrombospondin-1 (TSP1) protein which could activate Mφ is closely related to the colonic mucosal damage in UC. Here, we investigated the role of TSP1 in the differentiat...

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Detalles Bibliográficos
Autores principales: Tao, Ping, Zhang, Beiping, Lin, Jiang, Wang, Shiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743729/
https://www.ncbi.nlm.nih.gov/pubmed/35071432
http://dx.doi.org/10.21037/atm-21-6034

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