Cargando…
Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows
BACKGROUND AND AIM: Digital dermatitis (DD) is one of the most common causes of lameness in dairy cattle. It is seen in nearly all dairy herds across the world and has substantial welfare and economic implications. In this study, we aimed to investigate the efficacy of phenytoin sodium topical treat...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Veterinary World
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743774/ https://www.ncbi.nlm.nih.gov/pubmed/35017837 http://dx.doi.org/10.14202/vetworld.2021.2907-2912 |
_version_ | 1784629984405487616 |
---|---|
author | El-Shafaey, El-Sayed Hamed, Mohamed A. Elfadl, Eman Abo Gomaa, Naglaa A. Rizk, Mohamed Abdo |
author_facet | El-Shafaey, El-Sayed Hamed, Mohamed A. Elfadl, Eman Abo Gomaa, Naglaa A. Rizk, Mohamed Abdo |
author_sort | El-Shafaey, El-Sayed |
collection | PubMed |
description | BACKGROUND AND AIM: Digital dermatitis (DD) is one of the most common causes of lameness in dairy cattle. It is seen in nearly all dairy herds across the world and has substantial welfare and economic implications. In this study, we aimed to investigate the efficacy of phenytoin sodium topical treatment on painful ulcerative stage of bovine digital dermatitis (BDD). MATERIALS AND METHODS: In total, 45 Holstein-Friesian dairy cows with DD were randomly assigned to one of the three topical treatment trials (15 each): Saline solution (first treatment, negative control), chlortetracycline spray (second treatment, positive control), or phenytoin sodium powder (third treatment, positive control) (third treatment). On day 0 (pre-treatment) and on days 7, 14, 21, and 28 post-treatment, the response of DD-affected cows to the medications used was evaluated by measuring lesion depth and size, as well as the total clinical score (lameness, pain, and discomfort). RESULTS: The cure rate in cows treated with phenytoin (86.66%) on day 28 was significantly improved compared to cows treated with either chlortetracycline (60%) or normal saline (6.66 %). CONCLUSION: Our findings highlight the superiority of phenytoin over the commonly used antibacterial agent, chlortetracycline, in the topical treatment of BDD, and subsequently suggest that phenytoin should be considered a suitable alternative treatment option for the treatment of BDD. |
format | Online Article Text |
id | pubmed-8743774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Veterinary World |
record_format | MEDLINE/PubMed |
spelling | pubmed-87437742022-01-10 Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows El-Shafaey, El-Sayed Hamed, Mohamed A. Elfadl, Eman Abo Gomaa, Naglaa A. Rizk, Mohamed Abdo Vet World Research Article BACKGROUND AND AIM: Digital dermatitis (DD) is one of the most common causes of lameness in dairy cattle. It is seen in nearly all dairy herds across the world and has substantial welfare and economic implications. In this study, we aimed to investigate the efficacy of phenytoin sodium topical treatment on painful ulcerative stage of bovine digital dermatitis (BDD). MATERIALS AND METHODS: In total, 45 Holstein-Friesian dairy cows with DD were randomly assigned to one of the three topical treatment trials (15 each): Saline solution (first treatment, negative control), chlortetracycline spray (second treatment, positive control), or phenytoin sodium powder (third treatment, positive control) (third treatment). On day 0 (pre-treatment) and on days 7, 14, 21, and 28 post-treatment, the response of DD-affected cows to the medications used was evaluated by measuring lesion depth and size, as well as the total clinical score (lameness, pain, and discomfort). RESULTS: The cure rate in cows treated with phenytoin (86.66%) on day 28 was significantly improved compared to cows treated with either chlortetracycline (60%) or normal saline (6.66 %). CONCLUSION: Our findings highlight the superiority of phenytoin over the commonly used antibacterial agent, chlortetracycline, in the topical treatment of BDD, and subsequently suggest that phenytoin should be considered a suitable alternative treatment option for the treatment of BDD. Veterinary World 2021-11 2021-11-12 /pmc/articles/PMC8743774/ /pubmed/35017837 http://dx.doi.org/10.14202/vetworld.2021.2907-2912 Text en Copyright: © El-Shafaey, et al. https://creativecommons.org/licenses/by/4.0/Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article El-Shafaey, El-Sayed Hamed, Mohamed A. Elfadl, Eman Abo Gomaa, Naglaa A. Rizk, Mohamed Abdo Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows |
title | Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows |
title_full | Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows |
title_fullStr | Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows |
title_full_unstemmed | Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows |
title_short | Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows |
title_sort | phenytoin: a promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743774/ https://www.ncbi.nlm.nih.gov/pubmed/35017837 http://dx.doi.org/10.14202/vetworld.2021.2907-2912 |
work_keys_str_mv | AT elshafaeyelsayed phenytoinapromisingnonantibioticdrugforthetopicaltreatmentofdigitaldermatitisindairycows AT hamedmohameda phenytoinapromisingnonantibioticdrugforthetopicaltreatmentofdigitaldermatitisindairycows AT elfadlemanabo phenytoinapromisingnonantibioticdrugforthetopicaltreatmentofdigitaldermatitisindairycows AT gomaanaglaaa phenytoinapromisingnonantibioticdrugforthetopicaltreatmentofdigitaldermatitisindairycows AT rizkmohamedabdo phenytoinapromisingnonantibioticdrugforthetopicaltreatmentofdigitaldermatitisindairycows |