TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma

SMARCA4/BRG1-deficient lung adenocarcinoma (SD-LUAD) is being recognized as a distinct subtype based on subtle differences in its clinical, morphological, and immunophenotypic attributes compared to other non–small cell lung carcinomas. We present here a case of SD-LUAD with curious thyroid transcri...

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Detalles Bibliográficos
Autores principales: Mehta, Anurag, Diwan, Himanshi, Bansal, Divya, Gupta, Manoj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pathologists/The Korean Society for Cytopathology 2022
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743805/
https://www.ncbi.nlm.nih.gov/pubmed/34775734
http://dx.doi.org/10.4132/jptm.2021.09.16
Descripción
Sumario:SMARCA4/BRG1-deficient lung adenocarcinoma (SD-LUAD) is being recognized as a distinct subtype based on subtle differences in its clinical, morphological, and immunophenotypic attributes compared to other non–small cell lung carcinomas. We present here a case of SD-LUAD with curious thyroid transcription factor 1 (TTF1) expression in a morphologically heterogenous lung adenocarcinoma. The better differentiated area showed preservation of TTF1 expression, and a poorly differentiated tumor had loss of TTF1 expression with universal BRG1 loss.

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