Cargando…

TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma

SMARCA4/BRG1-deficient lung adenocarcinoma (SD-LUAD) is being recognized as a distinct subtype based on subtle differences in its clinical, morphological, and immunophenotypic attributes compared to other non–small cell lung carcinomas. We present here a case of SD-LUAD with curious thyroid transcri...

Descripción completa

Detalles Bibliográficos
Autores principales: Mehta, Anurag, Diwan, Himanshi, Bansal, Divya, Gupta, Manoj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pathologists/The Korean Society for Cytopathology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743805/
https://www.ncbi.nlm.nih.gov/pubmed/34775734
http://dx.doi.org/10.4132/jptm.2021.09.16
_version_ 1784629992220524544
author Mehta, Anurag
Diwan, Himanshi
Bansal, Divya
Gupta, Manoj
author_facet Mehta, Anurag
Diwan, Himanshi
Bansal, Divya
Gupta, Manoj
author_sort Mehta, Anurag
collection PubMed
description SMARCA4/BRG1-deficient lung adenocarcinoma (SD-LUAD) is being recognized as a distinct subtype based on subtle differences in its clinical, morphological, and immunophenotypic attributes compared to other non–small cell lung carcinomas. We present here a case of SD-LUAD with curious thyroid transcription factor 1 (TTF1) expression in a morphologically heterogenous lung adenocarcinoma. The better differentiated area showed preservation of TTF1 expression, and a poorly differentiated tumor had loss of TTF1 expression with universal BRG1 loss.
format Online
Article
Text
id pubmed-8743805
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Korean Society of Pathologists/The Korean Society for Cytopathology
record_format MEDLINE/PubMed
spelling pubmed-87438052022-01-18 TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma Mehta, Anurag Diwan, Himanshi Bansal, Divya Gupta, Manoj J Pathol Transl Med Case Study SMARCA4/BRG1-deficient lung adenocarcinoma (SD-LUAD) is being recognized as a distinct subtype based on subtle differences in its clinical, morphological, and immunophenotypic attributes compared to other non–small cell lung carcinomas. We present here a case of SD-LUAD with curious thyroid transcription factor 1 (TTF1) expression in a morphologically heterogenous lung adenocarcinoma. The better differentiated area showed preservation of TTF1 expression, and a poorly differentiated tumor had loss of TTF1 expression with universal BRG1 loss. The Korean Society of Pathologists/The Korean Society for Cytopathology 2022-01 2021-11-16 /pmc/articles/PMC8743805/ /pubmed/34775734 http://dx.doi.org/10.4132/jptm.2021.09.16 Text en © 2022 The Korean Society of Pathologists/The Korean Society for Cytopathology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Study
Mehta, Anurag
Diwan, Himanshi
Bansal, Divya
Gupta, Manoj
TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma
title TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma
title_full TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma
title_fullStr TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma
title_full_unstemmed TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma
title_short TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma
title_sort ttf1-positive smarca4/brg1 deficient lung adenocarcinoma
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743805/
https://www.ncbi.nlm.nih.gov/pubmed/34775734
http://dx.doi.org/10.4132/jptm.2021.09.16
work_keys_str_mv AT mehtaanurag ttf1positivesmarca4brg1deficientlungadenocarcinoma
AT diwanhimanshi ttf1positivesmarca4brg1deficientlungadenocarcinoma
AT bansaldivya ttf1positivesmarca4brg1deficientlungadenocarcinoma
AT guptamanoj ttf1positivesmarca4brg1deficientlungadenocarcinoma