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Cervical Spinal Cord Atrophy can be Accurately Quantified Using Head Images
BACKGROUND: Spinal cord atrophy provides a clinically relevant metric for monitoring MS. However, the spinal cord is imaged far less frequently than brain due to artefacts and acquisition time, whereas MRI of the brain is routinely performed. OBJECTIVE: To validate spinal cord cross-sectional area m...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743948/ https://www.ncbi.nlm.nih.gov/pubmed/35024164 http://dx.doi.org/10.1177/20552173211070760 |
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author | Taheri, Kamyar Vavasour, Irene M Abel, Shawna Lee, Lisa Eunyoung Johnson, Poljanka Ristow, Stephen Tam, Roger Laule, Cornelia Ackermans, Nathalie Chantal Schabas, Alice Cross, Helen Chan, Jillian Katrina Sayao, Ana-Luiza Bhan, Virender Devonshire, Virginia Carruthers, Robert Li, David KB Traboulsee, Anthony L Kolind, Shannon H Dvorak, Adam Vladimir |
author_facet | Taheri, Kamyar Vavasour, Irene M Abel, Shawna Lee, Lisa Eunyoung Johnson, Poljanka Ristow, Stephen Tam, Roger Laule, Cornelia Ackermans, Nathalie Chantal Schabas, Alice Cross, Helen Chan, Jillian Katrina Sayao, Ana-Luiza Bhan, Virender Devonshire, Virginia Carruthers, Robert Li, David KB Traboulsee, Anthony L Kolind, Shannon H Dvorak, Adam Vladimir |
author_sort | Taheri, Kamyar |
collection | PubMed |
description | BACKGROUND: Spinal cord atrophy provides a clinically relevant metric for monitoring MS. However, the spinal cord is imaged far less frequently than brain due to artefacts and acquisition time, whereas MRI of the brain is routinely performed. OBJECTIVE: To validate spinal cord cross-sectional area measurements from routine 3DT1 whole-brain MRI versus those from dedicated cord MRI in healthy controls and people with MS. METHODS: We calculated cross-sectional area at C1 and C2/3 using T2*-weighted spinal cord images and 3DT1 brain images, for 28 healthy controls and 73 people with MS. Correlations for both groups were assessed between: (1) C1 and C2/3 using cord images; (2) C1 from brain and C1 from cord; and (3) C1 from brain and C2/3 from cord. RESULTS AND CONCLUSION: C1 and C2/3 from cord were strongly correlated in controls (r = 0.94, p<0.0001) and MS (r = 0.85, p<0.0001). There was strong agreement between C1 from brain and C2/3 from cord in controls (r = 0.84, p<0.0001) and MS (r = 0.81, p<0.0001). This supports the use of C1 cross-sectional area calculated from brain imaging as a surrogate for the traditional C2/3 cross-sectional area measure for spinal cord atrophy. |
format | Online Article Text |
id | pubmed-8743948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-87439482022-01-11 Cervical Spinal Cord Atrophy can be Accurately Quantified Using Head Images Taheri, Kamyar Vavasour, Irene M Abel, Shawna Lee, Lisa Eunyoung Johnson, Poljanka Ristow, Stephen Tam, Roger Laule, Cornelia Ackermans, Nathalie Chantal Schabas, Alice Cross, Helen Chan, Jillian Katrina Sayao, Ana-Luiza Bhan, Virender Devonshire, Virginia Carruthers, Robert Li, David KB Traboulsee, Anthony L Kolind, Shannon H Dvorak, Adam Vladimir Mult Scler J Exp Transl Clin Original Research Article BACKGROUND: Spinal cord atrophy provides a clinically relevant metric for monitoring MS. However, the spinal cord is imaged far less frequently than brain due to artefacts and acquisition time, whereas MRI of the brain is routinely performed. OBJECTIVE: To validate spinal cord cross-sectional area measurements from routine 3DT1 whole-brain MRI versus those from dedicated cord MRI in healthy controls and people with MS. METHODS: We calculated cross-sectional area at C1 and C2/3 using T2*-weighted spinal cord images and 3DT1 brain images, for 28 healthy controls and 73 people with MS. Correlations for both groups were assessed between: (1) C1 and C2/3 using cord images; (2) C1 from brain and C1 from cord; and (3) C1 from brain and C2/3 from cord. RESULTS AND CONCLUSION: C1 and C2/3 from cord were strongly correlated in controls (r = 0.94, p<0.0001) and MS (r = 0.85, p<0.0001). There was strong agreement between C1 from brain and C2/3 from cord in controls (r = 0.84, p<0.0001) and MS (r = 0.81, p<0.0001). This supports the use of C1 cross-sectional area calculated from brain imaging as a surrogate for the traditional C2/3 cross-sectional area measure for spinal cord atrophy. SAGE Publications 2022-01-07 /pmc/articles/PMC8743948/ /pubmed/35024164 http://dx.doi.org/10.1177/20552173211070760 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Article Taheri, Kamyar Vavasour, Irene M Abel, Shawna Lee, Lisa Eunyoung Johnson, Poljanka Ristow, Stephen Tam, Roger Laule, Cornelia Ackermans, Nathalie Chantal Schabas, Alice Cross, Helen Chan, Jillian Katrina Sayao, Ana-Luiza Bhan, Virender Devonshire, Virginia Carruthers, Robert Li, David KB Traboulsee, Anthony L Kolind, Shannon H Dvorak, Adam Vladimir Cervical Spinal Cord Atrophy can be Accurately Quantified Using Head Images |
title | Cervical Spinal Cord Atrophy can be
Accurately Quantified Using Head Images |
title_full | Cervical Spinal Cord Atrophy can be
Accurately Quantified Using Head Images |
title_fullStr | Cervical Spinal Cord Atrophy can be
Accurately Quantified Using Head Images |
title_full_unstemmed | Cervical Spinal Cord Atrophy can be
Accurately Quantified Using Head Images |
title_short | Cervical Spinal Cord Atrophy can be
Accurately Quantified Using Head Images |
title_sort | cervical spinal cord atrophy can be
accurately quantified using head images |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743948/ https://www.ncbi.nlm.nih.gov/pubmed/35024164 http://dx.doi.org/10.1177/20552173211070760 |
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