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Therapeutic innovation for multi-resistant candidemics: Synergy of isavuconazole and caspofungin association

Fungal infections occurring in immunocompromised patients after immunochemotherapy treatment are often difficult to eradicate and capable of even being fatal. Systemic mycoses affecting severely immunocompromised patients often manifest acutely with rapidly progressive pneumonia, fungemia, or manife...

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Detalles Bibliográficos
Autores principales: Duminuco, Andrea, Mauro, Elisa, Palumbo, Giuseppe A. M., Garibaldi, Bruno, Parisi, Marina, Di Raimondo, Francesco, Maugeri, Cinzia, Vetro, Calogero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743983/
https://www.ncbi.nlm.nih.gov/pubmed/35070221
http://dx.doi.org/10.4081/hr.2021.9329
Descripción
Sumario:Fungal infections occurring in immunocompromised patients after immunochemotherapy treatment are often difficult to eradicate and capable of even being fatal. Systemic mycoses affecting severely immunocompromised patients often manifest acutely with rapidly progressive pneumonia, fungemia, or manifestations of extrapulmonary dissemination. Opportunistic fungal infections (mycoses) include several pathogens elements, as candidiasis, aspergillosis, mucormycosis (zygomycosis) and fusariosis. Prompt diagnosis and effective therapy are needed to improve the associated morbidity and mortality, especially in cases with non-canonical fungal localizations and not responsive to the available antifungal drugs.