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COVID-19 Infection and Late Manifestation of Pulmonary Aspergillosis
We present the case of a 56-year-old woman who was diagnosed with severe coronavirus disease 2019 (COVID-19) pneumonia complicated by severe acute respiratory distress syndrome who was intubated for 19 days. She recovered from COVID-19 after a month. A computed tomography (CT) scan of the chest, aft...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744194/ https://www.ncbi.nlm.nih.gov/pubmed/34984948 http://dx.doi.org/10.1177/23247096211063332 |
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author | Bhopalwala, Huzefa Mishra, Vinayak Do, Tuong Vi Gudipati, Mythili Ganti, Subramanya Shyam |
author_facet | Bhopalwala, Huzefa Mishra, Vinayak Do, Tuong Vi Gudipati, Mythili Ganti, Subramanya Shyam |
author_sort | Bhopalwala, Huzefa |
collection | PubMed |
description | We present the case of a 56-year-old woman who was diagnosed with severe coronavirus disease 2019 (COVID-19) pneumonia complicated by severe acute respiratory distress syndrome who was intubated for 19 days. She recovered from COVID-19 after a month. A computed tomography (CT) scan of the chest, after a month, showed improved infiltrates with a small residual cavity within the lingula. A CT angiogram showed a more confluent density in the lingular portion on follow-up 2 months later. She developed intermittent hemoptysis after 3 months in December 2020, which persisted for almost 6 months, and CT of the chest showed the lingular nodular with resolution of the cavitation. She underwent bronchoscopy with bronchoalveolar lavage, confirming Aspergillus fumigatus by galactomannan assay and histology showing branching hyphae. Once she started treatment with itraconazole, her hemoptysis resolved. The follow-up CT of the chest after 2 months of treatment did not show a cavity or a nodule in the lingula. Our patient developed invasive pulmonary aspergillosis (IPA) as a sequela of severe COVID-19 infection. COVID-19-associated invasive pulmonary aspergillosis (CAPA) is an underrecognized complication that needs to be investigated on whether prophylactic treatment is required. Our case also demonstrates that the diagnosis of IPA needs to be considered months after COVID-19 infection when a superimposed fungal infection can occur after a viral infection if the patient continues to have persistent symptoms. |
format | Online Article Text |
id | pubmed-8744194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-87441942022-01-11 COVID-19 Infection and Late Manifestation of Pulmonary Aspergillosis Bhopalwala, Huzefa Mishra, Vinayak Do, Tuong Vi Gudipati, Mythili Ganti, Subramanya Shyam J Investig Med High Impact Case Rep Case Report We present the case of a 56-year-old woman who was diagnosed with severe coronavirus disease 2019 (COVID-19) pneumonia complicated by severe acute respiratory distress syndrome who was intubated for 19 days. She recovered from COVID-19 after a month. A computed tomography (CT) scan of the chest, after a month, showed improved infiltrates with a small residual cavity within the lingula. A CT angiogram showed a more confluent density in the lingular portion on follow-up 2 months later. She developed intermittent hemoptysis after 3 months in December 2020, which persisted for almost 6 months, and CT of the chest showed the lingular nodular with resolution of the cavitation. She underwent bronchoscopy with bronchoalveolar lavage, confirming Aspergillus fumigatus by galactomannan assay and histology showing branching hyphae. Once she started treatment with itraconazole, her hemoptysis resolved. The follow-up CT of the chest after 2 months of treatment did not show a cavity or a nodule in the lingula. Our patient developed invasive pulmonary aspergillosis (IPA) as a sequela of severe COVID-19 infection. COVID-19-associated invasive pulmonary aspergillosis (CAPA) is an underrecognized complication that needs to be investigated on whether prophylactic treatment is required. Our case also demonstrates that the diagnosis of IPA needs to be considered months after COVID-19 infection when a superimposed fungal infection can occur after a viral infection if the patient continues to have persistent symptoms. SAGE Publications 2022-01-05 /pmc/articles/PMC8744194/ /pubmed/34984948 http://dx.doi.org/10.1177/23247096211063332 Text en © 2022 American Federation for Medical Research https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Bhopalwala, Huzefa Mishra, Vinayak Do, Tuong Vi Gudipati, Mythili Ganti, Subramanya Shyam COVID-19 Infection and Late Manifestation of Pulmonary Aspergillosis |
title | COVID-19 Infection and Late Manifestation of Pulmonary
Aspergillosis |
title_full | COVID-19 Infection and Late Manifestation of Pulmonary
Aspergillosis |
title_fullStr | COVID-19 Infection and Late Manifestation of Pulmonary
Aspergillosis |
title_full_unstemmed | COVID-19 Infection and Late Manifestation of Pulmonary
Aspergillosis |
title_short | COVID-19 Infection and Late Manifestation of Pulmonary
Aspergillosis |
title_sort | covid-19 infection and late manifestation of pulmonary
aspergillosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744194/ https://www.ncbi.nlm.nih.gov/pubmed/34984948 http://dx.doi.org/10.1177/23247096211063332 |
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