Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study

Mucin-1 (MUC-1) is a transmembrane glycoprotein, which bears many similarities between dogs and humans. Since the existence of animal models is essential to understand the significant factors involved in breast cancer mechanisms, canine mammary tumors (CMTs) could be used as a spontaneously occurrin...

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Autores principales: Vafaei, Rana, Samadi, Mitra, Hosseinzadeh, Aysooda, Barzaman, Khadijeh, Esmailinejad, MohammadReza, Khaki, Zohreh, Farahmand, Leila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744232/
https://www.ncbi.nlm.nih.gov/pubmed/35000604
http://dx.doi.org/10.1186/s12935-021-02398-6
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author Vafaei, Rana
Samadi, Mitra
Hosseinzadeh, Aysooda
Barzaman, Khadijeh
Esmailinejad, MohammadReza
Khaki, Zohreh
Farahmand, Leila
author_facet Vafaei, Rana
Samadi, Mitra
Hosseinzadeh, Aysooda
Barzaman, Khadijeh
Esmailinejad, MohammadReza
Khaki, Zohreh
Farahmand, Leila
author_sort Vafaei, Rana
collection PubMed
description Mucin-1 (MUC-1) is a transmembrane glycoprotein, which bears many similarities between dogs and humans. Since the existence of animal models is essential to understand the significant factors involved in breast cancer mechanisms, canine mammary tumors (CMTs) could be used as a spontaneously occurring tumor model for human studies. Accordingly, this review assessed the comparison of canine and human MUC-1 based on their diagnostic and therapeutic aspects and showed how comparative oncology approaches could provide insights into translating pre-clinical trials from human to veterinary oncology and vice versa which could benefit both humans and dogs.
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spelling pubmed-87442322022-01-11 Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study Vafaei, Rana Samadi, Mitra Hosseinzadeh, Aysooda Barzaman, Khadijeh Esmailinejad, MohammadReza Khaki, Zohreh Farahmand, Leila Cancer Cell Int Review Mucin-1 (MUC-1) is a transmembrane glycoprotein, which bears many similarities between dogs and humans. Since the existence of animal models is essential to understand the significant factors involved in breast cancer mechanisms, canine mammary tumors (CMTs) could be used as a spontaneously occurring tumor model for human studies. Accordingly, this review assessed the comparison of canine and human MUC-1 based on their diagnostic and therapeutic aspects and showed how comparative oncology approaches could provide insights into translating pre-clinical trials from human to veterinary oncology and vice versa which could benefit both humans and dogs. BioMed Central 2022-01-09 /pmc/articles/PMC8744232/ /pubmed/35000604 http://dx.doi.org/10.1186/s12935-021-02398-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Vafaei, Rana
Samadi, Mitra
Hosseinzadeh, Aysooda
Barzaman, Khadijeh
Esmailinejad, MohammadReza
Khaki, Zohreh
Farahmand, Leila
Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study
title Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study
title_full Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study
title_fullStr Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study
title_full_unstemmed Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study
title_short Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study
title_sort comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744232/
https://www.ncbi.nlm.nih.gov/pubmed/35000604
http://dx.doi.org/10.1186/s12935-021-02398-6
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