Knockout of circRNAs by base editing back-splice sites of circularized exons

Many circular RNAs (circRNAs) are produced from back-splicing of exons of precursor mRNAs and are generally co-expressed with cognate linear RNAs. Methods for circRNA-specific knockout are lacking, largely due to sequence overlaps between forms. Here, we use base editors (BEs) for circRNA depletion....

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Xiang, Ma, Xu-Kai, Li, Xiang, Li, Guo-Wei, Liu, Chu-Xiao, Zhang, Jun, Wang, Ying, Wei, Jia, Chen, Jia, Chen, Ling-Ling, Yang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744252/
https://www.ncbi.nlm.nih.gov/pubmed/35012611
http://dx.doi.org/10.1186/s13059-021-02563-0

Ejemplares similares

Ejemplares similares