Puromycin-based purification of cells with high expression of the cytochrome P450 CYP3A4 gene from a patient with drug-induced liver injury (DILI)

BACKGROUND: Many drugs have the potential to induce the expression of drug-metabolizing enzymes, particularly cytochrome P450 3A4 (CYP3A4), in hepatocytes. Hepatocytes can be accurately evaluated for drug-mediated CYP3A4 induction; this is the gold standard for in vitro hepatic toxicology testing. H...

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Detalles Bibliográficos
Autores principales: Miyata, Shoko, Saku, Noriaki, Akiyama, Saeko, Javaregowda, Palaksha Kanive, Ite, Kenta, Takashima, Nagisa, Toyoda, Masashi, Yura, Kei, Kimura, Tohru, Nishina, Hiroshi, Nakazawa, Atsuko, Kasahara, Mureo, Nonaka, Hidenori, Kiyono, Tohru, Umezawa, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744258/
https://www.ncbi.nlm.nih.gov/pubmed/35012658
http://dx.doi.org/10.1186/s13287-021-02680-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744258/
https://www.ncbi.nlm.nih.gov/pubmed/35012658
http://dx.doi.org/10.1186/s13287-021-02680-4

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