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Age-associated network controllability changes in first episode drug-naïve schizophrenia
BACKGROUND: Recent neuroimaging studies revealed dysregulated neurodevelopmental, or/and neurodegenerative trajectories of both structural and functional connections in schizophrenia. However, how the alterations in the brain’s structural connectivity lead to dynamic function changes in schizophreni...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744281/ https://www.ncbi.nlm.nih.gov/pubmed/35012507 http://dx.doi.org/10.1186/s12888-021-03674-5 |
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author | Tang, Biqiu Zhang, Wenjing Deng, Shikuang Liu, Jiang Hu, Na Gong, Qiyong Gu, Shi Lui, Su |
author_facet | Tang, Biqiu Zhang, Wenjing Deng, Shikuang Liu, Jiang Hu, Na Gong, Qiyong Gu, Shi Lui, Su |
author_sort | Tang, Biqiu |
collection | PubMed |
description | BACKGROUND: Recent neuroimaging studies revealed dysregulated neurodevelopmental, or/and neurodegenerative trajectories of both structural and functional connections in schizophrenia. However, how the alterations in the brain’s structural connectivity lead to dynamic function changes in schizophrenia with age remains poorly understood. METHODS: Combining structural magnetic resonance imaging and a network control theory approach, the white matter network controllability metric (average controllability) was mapped from age 16 to 60 years in 175 drug-naïve schizophrenia patients and 155 matched healthy controls. RESULTS: Compared with controls, the schizophrenia patients demonstrated the lack of age-related decrease on average controllability of default mode network (DMN), as well as the right precuneus (a hub region of DMN), suggesting abnormal maturational development process in schizophrenia. Interestingly, the schizophrenia patients demonstrated an accelerated age-related decline of average controllability in the subcortical network, supporting the neurodegenerative model. In addition, compared with controls, the lack of age-related increase on average controllability of the left inferior parietal gyrus in schizophrenia patients also suggested a different pathway of brain development. CONCLUSIONS: By applying the control theory approach, the present study revealed age-related changes in the ability of white matter pathways to control functional activity states in schizophrenia. The findings supported both the developmental and degenerative hypotheses of schizophrenia, and suggested a particularly high vulnerability of the DMN and subcortical network possibly reflecting an illness-related early marker for the disorder. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-021-03674-5. |
format | Online Article Text |
id | pubmed-8744281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-87442812022-01-11 Age-associated network controllability changes in first episode drug-naïve schizophrenia Tang, Biqiu Zhang, Wenjing Deng, Shikuang Liu, Jiang Hu, Na Gong, Qiyong Gu, Shi Lui, Su BMC Psychiatry Research BACKGROUND: Recent neuroimaging studies revealed dysregulated neurodevelopmental, or/and neurodegenerative trajectories of both structural and functional connections in schizophrenia. However, how the alterations in the brain’s structural connectivity lead to dynamic function changes in schizophrenia with age remains poorly understood. METHODS: Combining structural magnetic resonance imaging and a network control theory approach, the white matter network controllability metric (average controllability) was mapped from age 16 to 60 years in 175 drug-naïve schizophrenia patients and 155 matched healthy controls. RESULTS: Compared with controls, the schizophrenia patients demonstrated the lack of age-related decrease on average controllability of default mode network (DMN), as well as the right precuneus (a hub region of DMN), suggesting abnormal maturational development process in schizophrenia. Interestingly, the schizophrenia patients demonstrated an accelerated age-related decline of average controllability in the subcortical network, supporting the neurodegenerative model. In addition, compared with controls, the lack of age-related increase on average controllability of the left inferior parietal gyrus in schizophrenia patients also suggested a different pathway of brain development. CONCLUSIONS: By applying the control theory approach, the present study revealed age-related changes in the ability of white matter pathways to control functional activity states in schizophrenia. The findings supported both the developmental and degenerative hypotheses of schizophrenia, and suggested a particularly high vulnerability of the DMN and subcortical network possibly reflecting an illness-related early marker for the disorder. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-021-03674-5. BioMed Central 2022-01-10 /pmc/articles/PMC8744281/ /pubmed/35012507 http://dx.doi.org/10.1186/s12888-021-03674-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Tang, Biqiu Zhang, Wenjing Deng, Shikuang Liu, Jiang Hu, Na Gong, Qiyong Gu, Shi Lui, Su Age-associated network controllability changes in first episode drug-naïve schizophrenia |
title | Age-associated network controllability changes in first episode drug-naïve schizophrenia |
title_full | Age-associated network controllability changes in first episode drug-naïve schizophrenia |
title_fullStr | Age-associated network controllability changes in first episode drug-naïve schizophrenia |
title_full_unstemmed | Age-associated network controllability changes in first episode drug-naïve schizophrenia |
title_short | Age-associated network controllability changes in first episode drug-naïve schizophrenia |
title_sort | age-associated network controllability changes in first episode drug-naïve schizophrenia |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744281/ https://www.ncbi.nlm.nih.gov/pubmed/35012507 http://dx.doi.org/10.1186/s12888-021-03674-5 |
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