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Age-associated network controllability changes in first episode drug-naïve schizophrenia

BACKGROUND: Recent neuroimaging studies revealed dysregulated neurodevelopmental, or/and neurodegenerative trajectories of both structural and functional connections in schizophrenia. However, how the alterations in the brain’s structural connectivity lead to dynamic function changes in schizophreni...

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Autores principales: Tang, Biqiu, Zhang, Wenjing, Deng, Shikuang, Liu, Jiang, Hu, Na, Gong, Qiyong, Gu, Shi, Lui, Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744281/
https://www.ncbi.nlm.nih.gov/pubmed/35012507
http://dx.doi.org/10.1186/s12888-021-03674-5
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author Tang, Biqiu
Zhang, Wenjing
Deng, Shikuang
Liu, Jiang
Hu, Na
Gong, Qiyong
Gu, Shi
Lui, Su
author_facet Tang, Biqiu
Zhang, Wenjing
Deng, Shikuang
Liu, Jiang
Hu, Na
Gong, Qiyong
Gu, Shi
Lui, Su
author_sort Tang, Biqiu
collection PubMed
description BACKGROUND: Recent neuroimaging studies revealed dysregulated neurodevelopmental, or/and neurodegenerative trajectories of both structural and functional connections in schizophrenia. However, how the alterations in the brain’s structural connectivity lead to dynamic function changes in schizophrenia with age remains poorly understood. METHODS: Combining structural magnetic resonance imaging and a network control theory approach, the white matter network controllability metric (average controllability) was mapped from age 16 to 60 years in 175 drug-naïve schizophrenia patients and 155 matched healthy controls. RESULTS: Compared with controls, the schizophrenia patients demonstrated the lack of age-related decrease on average controllability of default mode network (DMN), as well as the right precuneus (a hub region of DMN), suggesting abnormal maturational development process in schizophrenia. Interestingly, the schizophrenia patients demonstrated an accelerated age-related decline of average controllability in the subcortical network, supporting the neurodegenerative model. In addition, compared with controls, the lack of age-related increase on average controllability of the left inferior parietal gyrus in schizophrenia patients also suggested a different pathway of brain development. CONCLUSIONS: By applying the control theory approach, the present study revealed age-related changes in the ability of white matter pathways to control functional activity states in schizophrenia. The findings supported both the developmental and degenerative hypotheses of schizophrenia, and suggested a particularly high vulnerability of the DMN and subcortical network possibly reflecting an illness-related early marker for the disorder. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-021-03674-5.
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spelling pubmed-87442812022-01-11 Age-associated network controllability changes in first episode drug-naïve schizophrenia Tang, Biqiu Zhang, Wenjing Deng, Shikuang Liu, Jiang Hu, Na Gong, Qiyong Gu, Shi Lui, Su BMC Psychiatry Research BACKGROUND: Recent neuroimaging studies revealed dysregulated neurodevelopmental, or/and neurodegenerative trajectories of both structural and functional connections in schizophrenia. However, how the alterations in the brain’s structural connectivity lead to dynamic function changes in schizophrenia with age remains poorly understood. METHODS: Combining structural magnetic resonance imaging and a network control theory approach, the white matter network controllability metric (average controllability) was mapped from age 16 to 60 years in 175 drug-naïve schizophrenia patients and 155 matched healthy controls. RESULTS: Compared with controls, the schizophrenia patients demonstrated the lack of age-related decrease on average controllability of default mode network (DMN), as well as the right precuneus (a hub region of DMN), suggesting abnormal maturational development process in schizophrenia. Interestingly, the schizophrenia patients demonstrated an accelerated age-related decline of average controllability in the subcortical network, supporting the neurodegenerative model. In addition, compared with controls, the lack of age-related increase on average controllability of the left inferior parietal gyrus in schizophrenia patients also suggested a different pathway of brain development. CONCLUSIONS: By applying the control theory approach, the present study revealed age-related changes in the ability of white matter pathways to control functional activity states in schizophrenia. The findings supported both the developmental and degenerative hypotheses of schizophrenia, and suggested a particularly high vulnerability of the DMN and subcortical network possibly reflecting an illness-related early marker for the disorder. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-021-03674-5. BioMed Central 2022-01-10 /pmc/articles/PMC8744281/ /pubmed/35012507 http://dx.doi.org/10.1186/s12888-021-03674-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Tang, Biqiu
Zhang, Wenjing
Deng, Shikuang
Liu, Jiang
Hu, Na
Gong, Qiyong
Gu, Shi
Lui, Su
Age-associated network controllability changes in first episode drug-naïve schizophrenia
title Age-associated network controllability changes in first episode drug-naïve schizophrenia
title_full Age-associated network controllability changes in first episode drug-naïve schizophrenia
title_fullStr Age-associated network controllability changes in first episode drug-naïve schizophrenia
title_full_unstemmed Age-associated network controllability changes in first episode drug-naïve schizophrenia
title_short Age-associated network controllability changes in first episode drug-naïve schizophrenia
title_sort age-associated network controllability changes in first episode drug-naïve schizophrenia
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744281/
https://www.ncbi.nlm.nih.gov/pubmed/35012507
http://dx.doi.org/10.1186/s12888-021-03674-5
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