3D hanging spheroid plate for high-throughput CAR T cell cytotoxicity assay

BACKGROUND: Most high-throughput screening (HTS) systems studying the cytotoxic effect of chimeric antigen receptor (CAR) T cells on tumor cells rely on two-dimensional cell culture that does not recapitulate the tumor microenvironment (TME). Tumor spheroids, however, can recapitulate the TME and ha...

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Detalles Bibliográficos
Autores principales: Chen, Zhenzhong, Han, Seokgyu, Sanny, Arleen, Chan, Dorothy Leung-Kwan, van Noort, Danny, Lim, Wanyoung, Tan, Andy Hee-Meng, Park, Sungsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744335/
https://www.ncbi.nlm.nih.gov/pubmed/35012567
http://dx.doi.org/10.1186/s12951-021-01213-8

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