Eugenol Administration Improves Liver Damage Induced by a Fructose-Rich Diet
BACKGROUNDS: The prevalence of metabolic syndrome (MetS) is increasing in developing countries that affects the liver in a variety of ways. This study was designed to investigate the protective role of eugenol on liver damage caused by fructose-induced MetS. MATERIALS AND METHODS: Thirty male Wistar...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744418/ https://www.ncbi.nlm.nih.gov/pubmed/35071110 http://dx.doi.org/10.4103/abr.abr_237_20 |
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author | Niazi, Abbass Ali Kourkinejad Gharaei, Fatemeh Saebinasab, Zahra Maleki, Maryam Maghool, Fatemeh Fereidooni, Fatemeh Safari, Tahereh |
author_facet | Niazi, Abbass Ali Kourkinejad Gharaei, Fatemeh Saebinasab, Zahra Maleki, Maryam Maghool, Fatemeh Fereidooni, Fatemeh Safari, Tahereh |
author_sort | Niazi, Abbass Ali |
collection | PubMed |
description | BACKGROUNDS: The prevalence of metabolic syndrome (MetS) is increasing in developing countries that affects the liver in a variety of ways. This study was designed to investigate the protective role of eugenol on liver damage caused by fructose-induced MetS. MATERIALS AND METHODS: Thirty male Wistar rats were randomly divided into five groups: 1: tap water (control), 2: fructose, 3: fructose + eugenol solvent, 4: fructose + eugenol 50 mg/kg, and 5: fructose + eugenol 100 mg/kg. At the end of the experiment, blood samples were taken for measurement fast blood glucose (FBG), serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT), low-density lipoprotein, high-density lipoprotein, cholesterol, and triglyceride. RESULTS: FBG significantly increased in Group 2 compared to Group 1 (P < 0.001); however, it significantly decreased in Groups 4 and 5 compared to Group 2 (P < 0.05). SGOT and SGPT levels significantly increased in Group 2 compared to the control group (P < 0.001). However, SGOT and SGPT levels significantly decreased in Groups 4 and 5. Malondialdehyde (MDA) and liver tissue damage score (LTDS) significantly increased in Group 2 compared with the control group (P < 0.01), whereas MDA and LTDS decreased in Groups 4 and 5 compared to Group 2 (P < 0.05). CONCLUSION: Eugenol may ameliorate liver damage in a rat model of fructose-induced MetS, and these protective effects may in part be mediated by improving antioxidant status and reducing oxidative stress and lipid peroxidation. It may also reduce hepatic inflammation and fat accumulation as well as fibrosis of liver cells. |
format | Online Article Text |
id | pubmed-8744418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-87444182022-01-21 Eugenol Administration Improves Liver Damage Induced by a Fructose-Rich Diet Niazi, Abbass Ali Kourkinejad Gharaei, Fatemeh Saebinasab, Zahra Maleki, Maryam Maghool, Fatemeh Fereidooni, Fatemeh Safari, Tahereh Adv Biomed Res Original Article BACKGROUNDS: The prevalence of metabolic syndrome (MetS) is increasing in developing countries that affects the liver in a variety of ways. This study was designed to investigate the protective role of eugenol on liver damage caused by fructose-induced MetS. MATERIALS AND METHODS: Thirty male Wistar rats were randomly divided into five groups: 1: tap water (control), 2: fructose, 3: fructose + eugenol solvent, 4: fructose + eugenol 50 mg/kg, and 5: fructose + eugenol 100 mg/kg. At the end of the experiment, blood samples were taken for measurement fast blood glucose (FBG), serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT), low-density lipoprotein, high-density lipoprotein, cholesterol, and triglyceride. RESULTS: FBG significantly increased in Group 2 compared to Group 1 (P < 0.001); however, it significantly decreased in Groups 4 and 5 compared to Group 2 (P < 0.05). SGOT and SGPT levels significantly increased in Group 2 compared to the control group (P < 0.001). However, SGOT and SGPT levels significantly decreased in Groups 4 and 5. Malondialdehyde (MDA) and liver tissue damage score (LTDS) significantly increased in Group 2 compared with the control group (P < 0.01), whereas MDA and LTDS decreased in Groups 4 and 5 compared to Group 2 (P < 0.05). CONCLUSION: Eugenol may ameliorate liver damage in a rat model of fructose-induced MetS, and these protective effects may in part be mediated by improving antioxidant status and reducing oxidative stress and lipid peroxidation. It may also reduce hepatic inflammation and fat accumulation as well as fibrosis of liver cells. Wolters Kluwer - Medknow 2021-11-26 /pmc/articles/PMC8744418/ /pubmed/35071110 http://dx.doi.org/10.4103/abr.abr_237_20 Text en Copyright: © 2021 Advanced Biomedical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Niazi, Abbass Ali Kourkinejad Gharaei, Fatemeh Saebinasab, Zahra Maleki, Maryam Maghool, Fatemeh Fereidooni, Fatemeh Safari, Tahereh Eugenol Administration Improves Liver Damage Induced by a Fructose-Rich Diet |
title | Eugenol Administration Improves Liver Damage Induced by a Fructose-Rich Diet |
title_full | Eugenol Administration Improves Liver Damage Induced by a Fructose-Rich Diet |
title_fullStr | Eugenol Administration Improves Liver Damage Induced by a Fructose-Rich Diet |
title_full_unstemmed | Eugenol Administration Improves Liver Damage Induced by a Fructose-Rich Diet |
title_short | Eugenol Administration Improves Liver Damage Induced by a Fructose-Rich Diet |
title_sort | eugenol administration improves liver damage induced by a fructose-rich diet |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744418/ https://www.ncbi.nlm.nih.gov/pubmed/35071110 http://dx.doi.org/10.4103/abr.abr_237_20 |
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