Cargando…

Diet, Sports, and Psychological Stress as Modulators of Breast Cancer Risk: Focus on OPRM1 Methylation

Background: DNA methylation is influenced by environmental factors and contributes to adverse modification of cancer risk and clinicopathological features. Methods: A case-control study (402 newly diagnosed cases, 470 controls) was conducted to evaluate the effect of environmental factors and OPRM1...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Liangliang, Li, Shuo, Qin, Shidong, Gao, Yu, Wang, Chao, Du, Jinghang, Zhang, Nannan, Chen, Yanbo, Han, Zhen, Yu, Yue, Wang, Fan, Zhao, Yashuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744450/
https://www.ncbi.nlm.nih.gov/pubmed/35024367
http://dx.doi.org/10.3389/fnut.2021.747964
_version_ 1784630118314934272
author Li, Liangliang
Li, Shuo
Qin, Shidong
Gao, Yu
Wang, Chao
Du, Jinghang
Zhang, Nannan
Chen, Yanbo
Han, Zhen
Yu, Yue
Wang, Fan
Zhao, Yashuang
author_facet Li, Liangliang
Li, Shuo
Qin, Shidong
Gao, Yu
Wang, Chao
Du, Jinghang
Zhang, Nannan
Chen, Yanbo
Han, Zhen
Yu, Yue
Wang, Fan
Zhao, Yashuang
author_sort Li, Liangliang
collection PubMed
description Background: DNA methylation is influenced by environmental factors and contributes to adverse modification of cancer risk and clinicopathological features. Methods: A case-control study (402 newly diagnosed cases, 470 controls) was conducted to evaluate the effect of environmental factors and OPRM1 methylation in peripheral blood leukocyte (PBL) DNA on the risk of breast cancer. A case-only study (373 cases) was designed to evaluate the effects of environmental factors on OPRM1 methylation in tumor tissue and the relationship of methylation with clinicopathological features. Results: We found a significant association between hypermethylation of OPRM1 and the risk of breast cancer (OR = 1.914, 95%CI = 1.357–2.777). OPRM1 hypermethylation in PBL DNA combined with low intake of vegetable, garlic, soybean, poultry, and milk; high pork intake; less regular sports and a high psychological stress index significantly increased the risk of breast cancer. Soybean intake (OR = 0.425, 95%CI: 0.231–0.781) and regular sports (OR = 0.624, 95%CI: 0.399–0.976) were associated with OPRM1 hypermethylation in tumor DNA. OPRM1 hypermethylation in tumor tissue was correlated with estrogen receptor (ER) (OR = 1.945, 95%CI: 1.262–2.996) and progesterone receptor (PR) (OR = 1.611, 95%CI: 1.069–2.427) negative status; in addition, OPRM1 hypermethylation in PBL DNA was associated with human epidermal growth factor receptor 2 (HER-2) negative status (OR = 3.673, 95%CI: 1.411–9.564). Conclusion: A healthy diet, psychosocial adaptability, and regular sports are very beneficial for breast cancer prevention and progress, especially for OPRM1 hypermethylation carriers. Personalized treatment considering the correlation between OPRM1 hypermethylation and ER and PR status may provide a novel benefit for breast cancer patients.
format Online
Article
Text
id pubmed-8744450
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87444502022-01-11 Diet, Sports, and Psychological Stress as Modulators of Breast Cancer Risk: Focus on OPRM1 Methylation Li, Liangliang Li, Shuo Qin, Shidong Gao, Yu Wang, Chao Du, Jinghang Zhang, Nannan Chen, Yanbo Han, Zhen Yu, Yue Wang, Fan Zhao, Yashuang Front Nutr Nutrition Background: DNA methylation is influenced by environmental factors and contributes to adverse modification of cancer risk and clinicopathological features. Methods: A case-control study (402 newly diagnosed cases, 470 controls) was conducted to evaluate the effect of environmental factors and OPRM1 methylation in peripheral blood leukocyte (PBL) DNA on the risk of breast cancer. A case-only study (373 cases) was designed to evaluate the effects of environmental factors on OPRM1 methylation in tumor tissue and the relationship of methylation with clinicopathological features. Results: We found a significant association between hypermethylation of OPRM1 and the risk of breast cancer (OR = 1.914, 95%CI = 1.357–2.777). OPRM1 hypermethylation in PBL DNA combined with low intake of vegetable, garlic, soybean, poultry, and milk; high pork intake; less regular sports and a high psychological stress index significantly increased the risk of breast cancer. Soybean intake (OR = 0.425, 95%CI: 0.231–0.781) and regular sports (OR = 0.624, 95%CI: 0.399–0.976) were associated with OPRM1 hypermethylation in tumor DNA. OPRM1 hypermethylation in tumor tissue was correlated with estrogen receptor (ER) (OR = 1.945, 95%CI: 1.262–2.996) and progesterone receptor (PR) (OR = 1.611, 95%CI: 1.069–2.427) negative status; in addition, OPRM1 hypermethylation in PBL DNA was associated with human epidermal growth factor receptor 2 (HER-2) negative status (OR = 3.673, 95%CI: 1.411–9.564). Conclusion: A healthy diet, psychosocial adaptability, and regular sports are very beneficial for breast cancer prevention and progress, especially for OPRM1 hypermethylation carriers. Personalized treatment considering the correlation between OPRM1 hypermethylation and ER and PR status may provide a novel benefit for breast cancer patients. Frontiers Media S.A. 2021-12-08 /pmc/articles/PMC8744450/ /pubmed/35024367 http://dx.doi.org/10.3389/fnut.2021.747964 Text en Copyright © 2021 Li, Li, Qin, Gao, Wang, Du, Zhang, Chen, Han, Yu, Wang and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Li, Liangliang
Li, Shuo
Qin, Shidong
Gao, Yu
Wang, Chao
Du, Jinghang
Zhang, Nannan
Chen, Yanbo
Han, Zhen
Yu, Yue
Wang, Fan
Zhao, Yashuang
Diet, Sports, and Psychological Stress as Modulators of Breast Cancer Risk: Focus on OPRM1 Methylation
title Diet, Sports, and Psychological Stress as Modulators of Breast Cancer Risk: Focus on OPRM1 Methylation
title_full Diet, Sports, and Psychological Stress as Modulators of Breast Cancer Risk: Focus on OPRM1 Methylation
title_fullStr Diet, Sports, and Psychological Stress as Modulators of Breast Cancer Risk: Focus on OPRM1 Methylation
title_full_unstemmed Diet, Sports, and Psychological Stress as Modulators of Breast Cancer Risk: Focus on OPRM1 Methylation
title_short Diet, Sports, and Psychological Stress as Modulators of Breast Cancer Risk: Focus on OPRM1 Methylation
title_sort diet, sports, and psychological stress as modulators of breast cancer risk: focus on oprm1 methylation
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744450/
https://www.ncbi.nlm.nih.gov/pubmed/35024367
http://dx.doi.org/10.3389/fnut.2021.747964
work_keys_str_mv AT liliangliang dietsportsandpsychologicalstressasmodulatorsofbreastcancerriskfocusonoprm1methylation
AT lishuo dietsportsandpsychologicalstressasmodulatorsofbreastcancerriskfocusonoprm1methylation
AT qinshidong dietsportsandpsychologicalstressasmodulatorsofbreastcancerriskfocusonoprm1methylation
AT gaoyu dietsportsandpsychologicalstressasmodulatorsofbreastcancerriskfocusonoprm1methylation
AT wangchao dietsportsandpsychologicalstressasmodulatorsofbreastcancerriskfocusonoprm1methylation
AT dujinghang dietsportsandpsychologicalstressasmodulatorsofbreastcancerriskfocusonoprm1methylation
AT zhangnannan dietsportsandpsychologicalstressasmodulatorsofbreastcancerriskfocusonoprm1methylation
AT chenyanbo dietsportsandpsychologicalstressasmodulatorsofbreastcancerriskfocusonoprm1methylation
AT hanzhen dietsportsandpsychologicalstressasmodulatorsofbreastcancerriskfocusonoprm1methylation
AT yuyue dietsportsandpsychologicalstressasmodulatorsofbreastcancerriskfocusonoprm1methylation
AT wangfan dietsportsandpsychologicalstressasmodulatorsofbreastcancerriskfocusonoprm1methylation
AT zhaoyashuang dietsportsandpsychologicalstressasmodulatorsofbreastcancerriskfocusonoprm1methylation