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Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer

Lung cancer is the leading cause of death from cancer in Taiwan and throughout the world. Immunotherapy has revealed promising and significant efficacy in NSCLC, through immune checkpoint inhibition by blocking programmed cell death protein (PD)-1/PD-1 ligand (PD-L1) signaling pathway to restore pat...

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Autores principales: Luo, Yung-Hung, Yang, Yi-Ping, Chien, Chian-Shiu, Yarmishyn, Aliaksandr A., Adekunle Ishola, Afeez, Chien, Yueh, Chen, Yuh-Min, Tsai, Ping-Hsing, Lin, Tzu-Wei, Wang, Mong-Lien, Chiou, Shih-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744551/
https://www.ncbi.nlm.nih.gov/pubmed/35008490
http://dx.doi.org/10.3390/ijms23010064
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author Luo, Yung-Hung
Yang, Yi-Ping
Chien, Chian-Shiu
Yarmishyn, Aliaksandr A.
Adekunle Ishola, Afeez
Chien, Yueh
Chen, Yuh-Min
Tsai, Ping-Hsing
Lin, Tzu-Wei
Wang, Mong-Lien
Chiou, Shih-Hwa
author_facet Luo, Yung-Hung
Yang, Yi-Ping
Chien, Chian-Shiu
Yarmishyn, Aliaksandr A.
Adekunle Ishola, Afeez
Chien, Yueh
Chen, Yuh-Min
Tsai, Ping-Hsing
Lin, Tzu-Wei
Wang, Mong-Lien
Chiou, Shih-Hwa
author_sort Luo, Yung-Hung
collection PubMed
description Lung cancer is the leading cause of death from cancer in Taiwan and throughout the world. Immunotherapy has revealed promising and significant efficacy in NSCLC, through immune checkpoint inhibition by blocking programmed cell death protein (PD)-1/PD-1 ligand (PD-L1) signaling pathway to restore patients’ T-cell immunity. One novel type of long, non-coding RNAs, circular RNAs (circRNAs), are endogenous, stable, and widely expressed in tissues, saliva, blood, urine, and exosomes. Our previous results revealed that the plasma level of hsa_circ_0000190 can be monitored by liquid-biopsy-based droplet digital PCR and may serve as a valuable blood-based biomarker to monitor the disease progression and the efficacy of immunotherapy. In this study, hsa_circ_0000190 was shown to increase the PD-L1 mRNA-mediated soluble PD-L1 (sPD-L1) expression, consequently interfering with the efficacy of anti-PD-L1 antibody and T-cell activation, which may result in immunotherapy resistance and poor outcome. Our results unraveled that hsa_circ_0000190 facilitated the tumorigenesis and immune evasion of NSCLC by upregulating sPD-L1 expression, potentially developing a different aspect in elucidating the molecular immunopathogenesis of NSCLC. Hsa_circ_0000190 upregulation can be an effective indicator for the progression of NSCLC, and hsa_circ_0000190 downregulation may possess a potential therapeutic value for the treatment of NSCLC in combination with immunotherapy.
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spelling pubmed-87445512022-01-11 Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer Luo, Yung-Hung Yang, Yi-Ping Chien, Chian-Shiu Yarmishyn, Aliaksandr A. Adekunle Ishola, Afeez Chien, Yueh Chen, Yuh-Min Tsai, Ping-Hsing Lin, Tzu-Wei Wang, Mong-Lien Chiou, Shih-Hwa Int J Mol Sci Article Lung cancer is the leading cause of death from cancer in Taiwan and throughout the world. Immunotherapy has revealed promising and significant efficacy in NSCLC, through immune checkpoint inhibition by blocking programmed cell death protein (PD)-1/PD-1 ligand (PD-L1) signaling pathway to restore patients’ T-cell immunity. One novel type of long, non-coding RNAs, circular RNAs (circRNAs), are endogenous, stable, and widely expressed in tissues, saliva, blood, urine, and exosomes. Our previous results revealed that the plasma level of hsa_circ_0000190 can be monitored by liquid-biopsy-based droplet digital PCR and may serve as a valuable blood-based biomarker to monitor the disease progression and the efficacy of immunotherapy. In this study, hsa_circ_0000190 was shown to increase the PD-L1 mRNA-mediated soluble PD-L1 (sPD-L1) expression, consequently interfering with the efficacy of anti-PD-L1 antibody and T-cell activation, which may result in immunotherapy resistance and poor outcome. Our results unraveled that hsa_circ_0000190 facilitated the tumorigenesis and immune evasion of NSCLC by upregulating sPD-L1 expression, potentially developing a different aspect in elucidating the molecular immunopathogenesis of NSCLC. Hsa_circ_0000190 upregulation can be an effective indicator for the progression of NSCLC, and hsa_circ_0000190 downregulation may possess a potential therapeutic value for the treatment of NSCLC in combination with immunotherapy. MDPI 2021-12-22 /pmc/articles/PMC8744551/ /pubmed/35008490 http://dx.doi.org/10.3390/ijms23010064 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Luo, Yung-Hung
Yang, Yi-Ping
Chien, Chian-Shiu
Yarmishyn, Aliaksandr A.
Adekunle Ishola, Afeez
Chien, Yueh
Chen, Yuh-Min
Tsai, Ping-Hsing
Lin, Tzu-Wei
Wang, Mong-Lien
Chiou, Shih-Hwa
Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer
title Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer
title_full Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer
title_fullStr Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer
title_full_unstemmed Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer
title_short Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer
title_sort circular rna hsa_circ_0000190 facilitates the tumorigenesis and immune evasion by upregulating the expression of soluble pd-l1 in non-small-cell lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744551/
https://www.ncbi.nlm.nih.gov/pubmed/35008490
http://dx.doi.org/10.3390/ijms23010064
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