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The Role of Exosomes in Cancer Progression
Early detection, characterization and monitoring of cancer are possible by using extracellular vesicles (EVs) isolated from non-invasively obtained liquid biopsy samples. They play a role in intercellular communication contributing to cell growth, differentiation and survival, thereby affecting the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744561/ https://www.ncbi.nlm.nih.gov/pubmed/35008434 http://dx.doi.org/10.3390/ijms23010008 |
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author | Soltész, Beáta Buglyó, Gergely Németh, Nikolett Szilágyi, Melinda Pös, Ondrej Szemes, Tomas Balogh, István Nagy, Bálint |
author_facet | Soltész, Beáta Buglyó, Gergely Németh, Nikolett Szilágyi, Melinda Pös, Ondrej Szemes, Tomas Balogh, István Nagy, Bálint |
author_sort | Soltész, Beáta |
collection | PubMed |
description | Early detection, characterization and monitoring of cancer are possible by using extracellular vesicles (EVs) isolated from non-invasively obtained liquid biopsy samples. They play a role in intercellular communication contributing to cell growth, differentiation and survival, thereby affecting the formation of tumor microenvironments and causing metastases. EVs were discovered more than seventy years ago. They have been tested recently as tools of drug delivery to treat cancer. Here we give a brief review on extracellular vesicles, exosomes, microvesicles and apoptotic bodies. Exosomes play an important role by carrying extracellular nucleic acids (DNA, RNA) in cell-to-cell communication causing tumor and metastasis development. We discuss the role of extracellular vesicles in the pathogenesis of cancer and their practical application in the early diagnosis, follow up, and next-generation treatment of cancer patients. |
format | Online Article Text |
id | pubmed-8744561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87445612022-01-11 The Role of Exosomes in Cancer Progression Soltész, Beáta Buglyó, Gergely Németh, Nikolett Szilágyi, Melinda Pös, Ondrej Szemes, Tomas Balogh, István Nagy, Bálint Int J Mol Sci Review Early detection, characterization and monitoring of cancer are possible by using extracellular vesicles (EVs) isolated from non-invasively obtained liquid biopsy samples. They play a role in intercellular communication contributing to cell growth, differentiation and survival, thereby affecting the formation of tumor microenvironments and causing metastases. EVs were discovered more than seventy years ago. They have been tested recently as tools of drug delivery to treat cancer. Here we give a brief review on extracellular vesicles, exosomes, microvesicles and apoptotic bodies. Exosomes play an important role by carrying extracellular nucleic acids (DNA, RNA) in cell-to-cell communication causing tumor and metastasis development. We discuss the role of extracellular vesicles in the pathogenesis of cancer and their practical application in the early diagnosis, follow up, and next-generation treatment of cancer patients. MDPI 2021-12-21 /pmc/articles/PMC8744561/ /pubmed/35008434 http://dx.doi.org/10.3390/ijms23010008 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Soltész, Beáta Buglyó, Gergely Németh, Nikolett Szilágyi, Melinda Pös, Ondrej Szemes, Tomas Balogh, István Nagy, Bálint The Role of Exosomes in Cancer Progression |
title | The Role of Exosomes in Cancer Progression |
title_full | The Role of Exosomes in Cancer Progression |
title_fullStr | The Role of Exosomes in Cancer Progression |
title_full_unstemmed | The Role of Exosomes in Cancer Progression |
title_short | The Role of Exosomes in Cancer Progression |
title_sort | role of exosomes in cancer progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744561/ https://www.ncbi.nlm.nih.gov/pubmed/35008434 http://dx.doi.org/10.3390/ijms23010008 |
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