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Overcoming Depression with 5-HT(2A) Receptor Ligands

Depression is a multifactorial disorder that affects millions of people worldwide, and none of the currently available therapeutics can completely cure it. Thus, there is a need for developing novel, potent, and safer agents. Recent medicinal chemistry findings on the structure and function of the s...

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Autores principales: Zięba, Agata, Stępnicki, Piotr, Matosiuk, Dariusz, Kaczor, Agnieszka A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744644/
https://www.ncbi.nlm.nih.gov/pubmed/35008436
http://dx.doi.org/10.3390/ijms23010010
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author Zięba, Agata
Stępnicki, Piotr
Matosiuk, Dariusz
Kaczor, Agnieszka A.
author_facet Zięba, Agata
Stępnicki, Piotr
Matosiuk, Dariusz
Kaczor, Agnieszka A.
author_sort Zięba, Agata
collection PubMed
description Depression is a multifactorial disorder that affects millions of people worldwide, and none of the currently available therapeutics can completely cure it. Thus, there is a need for developing novel, potent, and safer agents. Recent medicinal chemistry findings on the structure and function of the serotonin 2A (5-HT(2A)) receptor facilitated design and discovery of novel compounds with antidepressant action. Eligible papers highlighting the importance of 5-HT(2A) receptors in the pathomechanism of the disorder were identified in the content-screening performed on the popular databases (PubMed, Google Scholar). Articles were critically assessed based on their titles and abstracts. The most accurate papers were chosen to be read and presented in the manuscript. The review summarizes current knowledge on the applicability of 5-HT(2A) receptor signaling modulators in the treatment of depression. It provides an insight into the structural and physiological features of this receptor. Moreover, it presents an overview of recently conducted virtual screening campaigns aiming to identify novel, potent 5-HT(2A) receptor ligands and additional data on currently synthesized ligands acting through this protein.
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spelling pubmed-87446442022-01-11 Overcoming Depression with 5-HT(2A) Receptor Ligands Zięba, Agata Stępnicki, Piotr Matosiuk, Dariusz Kaczor, Agnieszka A. Int J Mol Sci Review Depression is a multifactorial disorder that affects millions of people worldwide, and none of the currently available therapeutics can completely cure it. Thus, there is a need for developing novel, potent, and safer agents. Recent medicinal chemistry findings on the structure and function of the serotonin 2A (5-HT(2A)) receptor facilitated design and discovery of novel compounds with antidepressant action. Eligible papers highlighting the importance of 5-HT(2A) receptors in the pathomechanism of the disorder were identified in the content-screening performed on the popular databases (PubMed, Google Scholar). Articles were critically assessed based on their titles and abstracts. The most accurate papers were chosen to be read and presented in the manuscript. The review summarizes current knowledge on the applicability of 5-HT(2A) receptor signaling modulators in the treatment of depression. It provides an insight into the structural and physiological features of this receptor. Moreover, it presents an overview of recently conducted virtual screening campaigns aiming to identify novel, potent 5-HT(2A) receptor ligands and additional data on currently synthesized ligands acting through this protein. MDPI 2021-12-21 /pmc/articles/PMC8744644/ /pubmed/35008436 http://dx.doi.org/10.3390/ijms23010010 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zięba, Agata
Stępnicki, Piotr
Matosiuk, Dariusz
Kaczor, Agnieszka A.
Overcoming Depression with 5-HT(2A) Receptor Ligands
title Overcoming Depression with 5-HT(2A) Receptor Ligands
title_full Overcoming Depression with 5-HT(2A) Receptor Ligands
title_fullStr Overcoming Depression with 5-HT(2A) Receptor Ligands
title_full_unstemmed Overcoming Depression with 5-HT(2A) Receptor Ligands
title_short Overcoming Depression with 5-HT(2A) Receptor Ligands
title_sort overcoming depression with 5-ht(2a) receptor ligands
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744644/
https://www.ncbi.nlm.nih.gov/pubmed/35008436
http://dx.doi.org/10.3390/ijms23010010
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