Low-frequency somatic copy number alterations in normal human lymphocytes revealed by large-scale single-cell whole-genome profiling

Genomic-scale somatic copy number alterations in healthy humans are difficult to investigate because of low occurrence rates and the structural variations’ stochastic natures. Using a Tn5-transposase-assisted single-cell whole-genome sequencing method, we sequenced over 20,000 single lymphocytes fro...

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Detalles Bibliográficos
Autores principales: Liu, Lu, Chen, He, Sun, Cheng, Zhang, Jianyun, Wang, Juncheng, Du, Meijie, Li, Jie, Di, Lin, Shen, Jie, Geng, Shuang, Pang, Yuhong, Luo, Yingying, Wu, Chen, Fu, Yusi, Zheng, Zhe, Wang, Jianbin, Huang, Yanyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744674/
https://www.ncbi.nlm.nih.gov/pubmed/34963662
http://dx.doi.org/10.1101/gr.275453.121

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