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Effects of Melatonin on Diabetic Neuropathy and Retinopathy

Diabetes mellitus (DM) leads to complications, the majority of which are nephropathy, retinopathy, and neuropathy. Redox imbalance and inflammation are important components of the pathophysiology of these complications. Many studies have been conducted to find a specific treatment for these neural c...

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Autores principales: Oliveira-Abreu, Klausen, Cipolla-Neto, José, Leal-Cardoso, Jose Henrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744787/
https://www.ncbi.nlm.nih.gov/pubmed/35008523
http://dx.doi.org/10.3390/ijms23010100
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author Oliveira-Abreu, Klausen
Cipolla-Neto, José
Leal-Cardoso, Jose Henrique
author_facet Oliveira-Abreu, Klausen
Cipolla-Neto, José
Leal-Cardoso, Jose Henrique
author_sort Oliveira-Abreu, Klausen
collection PubMed
description Diabetes mellitus (DM) leads to complications, the majority of which are nephropathy, retinopathy, and neuropathy. Redox imbalance and inflammation are important components of the pathophysiology of these complications. Many studies have been conducted to find a specific treatment for these neural complications, and some of them have investigated the therapeutic potential of melatonin (MEL), an anti-inflammatory agent and powerful antioxidant. In the present article, we review studies published over the past 21 years on the therapeutic efficacy of MEL in the treatment of DM-induced neural complications. Reports suggest that there is a real prospect of using MEL as an adjuvant treatment for hypoglycemic agents. However, analysis shows that there is a wide range of approaches regarding the doses used, duration of treatment, and treatment times in relation to the temporal course of DM. This wide range hinders an objective analysis of advances and prospective vision of the paths to be followed for the unequivocal establishment of parameters to be used in an eventual therapeutic validation of MEL in neural complications of DM.
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spelling pubmed-87447872022-01-11 Effects of Melatonin on Diabetic Neuropathy and Retinopathy Oliveira-Abreu, Klausen Cipolla-Neto, José Leal-Cardoso, Jose Henrique Int J Mol Sci Review Diabetes mellitus (DM) leads to complications, the majority of which are nephropathy, retinopathy, and neuropathy. Redox imbalance and inflammation are important components of the pathophysiology of these complications. Many studies have been conducted to find a specific treatment for these neural complications, and some of them have investigated the therapeutic potential of melatonin (MEL), an anti-inflammatory agent and powerful antioxidant. In the present article, we review studies published over the past 21 years on the therapeutic efficacy of MEL in the treatment of DM-induced neural complications. Reports suggest that there is a real prospect of using MEL as an adjuvant treatment for hypoglycemic agents. However, analysis shows that there is a wide range of approaches regarding the doses used, duration of treatment, and treatment times in relation to the temporal course of DM. This wide range hinders an objective analysis of advances and prospective vision of the paths to be followed for the unequivocal establishment of parameters to be used in an eventual therapeutic validation of MEL in neural complications of DM. MDPI 2021-12-22 /pmc/articles/PMC8744787/ /pubmed/35008523 http://dx.doi.org/10.3390/ijms23010100 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oliveira-Abreu, Klausen
Cipolla-Neto, José
Leal-Cardoso, Jose Henrique
Effects of Melatonin on Diabetic Neuropathy and Retinopathy
title Effects of Melatonin on Diabetic Neuropathy and Retinopathy
title_full Effects of Melatonin on Diabetic Neuropathy and Retinopathy
title_fullStr Effects of Melatonin on Diabetic Neuropathy and Retinopathy
title_full_unstemmed Effects of Melatonin on Diabetic Neuropathy and Retinopathy
title_short Effects of Melatonin on Diabetic Neuropathy and Retinopathy
title_sort effects of melatonin on diabetic neuropathy and retinopathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744787/
https://www.ncbi.nlm.nih.gov/pubmed/35008523
http://dx.doi.org/10.3390/ijms23010100
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