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Prenatal Metal Exposures and Infants’ Developmental Outcomes in a Navajo Population

Early-life exposure to environmental toxicants can have detrimental effects on children’s neurodevelopment. In the current study, we employed a causal modeling framework to examine the direct effect of specific maternal prenatal exposures on infants’ neurodevelopment in the context of co-occurring m...

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Autores principales: Nozadi, Sara S., Li, Li, Luo, Li, MacKenzie, Debra, Erdei, Esther, Du, Ruofei, Roman, Carolyn W., Hoover, Joseph, O’Donald, Elena, Burnette, Courtney, Lewis, Johnnye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744969/
https://www.ncbi.nlm.nih.gov/pubmed/35010683
http://dx.doi.org/10.3390/ijerph19010425
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author Nozadi, Sara S.
Li, Li
Luo, Li
MacKenzie, Debra
Erdei, Esther
Du, Ruofei
Roman, Carolyn W.
Hoover, Joseph
O’Donald, Elena
Burnette, Courtney
Lewis, Johnnye
author_facet Nozadi, Sara S.
Li, Li
Luo, Li
MacKenzie, Debra
Erdei, Esther
Du, Ruofei
Roman, Carolyn W.
Hoover, Joseph
O’Donald, Elena
Burnette, Courtney
Lewis, Johnnye
author_sort Nozadi, Sara S.
collection PubMed
description Early-life exposure to environmental toxicants can have detrimental effects on children’s neurodevelopment. In the current study, we employed a causal modeling framework to examine the direct effect of specific maternal prenatal exposures on infants’ neurodevelopment in the context of co-occurring metals. Maternal metal exposure and select micronutrients’ concentrations were assessed using samples collected at the time of delivery from mothers living across Navajo Nation with community exposure to metal mixtures originating from abandoned uranium mines. Infants’ development across five domains was measured at ages 10 to 13 months using the Ages and Stages Questionnaire Inventory (ASQ:I), an early developmental screener. After adjusting for effects of other confounding metals and demographic variables, prenatal exposure to lead, arsenic, antimony, barium, copper, and molybdenum predicted deficits in at least one of the ASQ:I domain scores. Strontium, tungsten, and thallium were positively associated with several aspects of infants’ development. Mothers with lower socioeconomic status (SES) had higher lead, cesium, and thallium exposures compared to mothers from high SES backgrounds. These mothers also had infants with lower scores across various developmental domains. The current study has many strengths including its focus on neurodevelopmental outcomes during infancy, an understudied developmental period, and the use of a novel analytical method to control for the effects of co-occurring metals while examining the effect of each metal on neurodevelopmental outcomes. Yet, future examination of how the effects of prenatal exposure on neurodevelopmental outcomes unfold over time while considering all potential interactions among metals and micronutrients is warranted.
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spelling pubmed-87449692022-01-11 Prenatal Metal Exposures and Infants’ Developmental Outcomes in a Navajo Population Nozadi, Sara S. Li, Li Luo, Li MacKenzie, Debra Erdei, Esther Du, Ruofei Roman, Carolyn W. Hoover, Joseph O’Donald, Elena Burnette, Courtney Lewis, Johnnye Int J Environ Res Public Health Article Early-life exposure to environmental toxicants can have detrimental effects on children’s neurodevelopment. In the current study, we employed a causal modeling framework to examine the direct effect of specific maternal prenatal exposures on infants’ neurodevelopment in the context of co-occurring metals. Maternal metal exposure and select micronutrients’ concentrations were assessed using samples collected at the time of delivery from mothers living across Navajo Nation with community exposure to metal mixtures originating from abandoned uranium mines. Infants’ development across five domains was measured at ages 10 to 13 months using the Ages and Stages Questionnaire Inventory (ASQ:I), an early developmental screener. After adjusting for effects of other confounding metals and demographic variables, prenatal exposure to lead, arsenic, antimony, barium, copper, and molybdenum predicted deficits in at least one of the ASQ:I domain scores. Strontium, tungsten, and thallium were positively associated with several aspects of infants’ development. Mothers with lower socioeconomic status (SES) had higher lead, cesium, and thallium exposures compared to mothers from high SES backgrounds. These mothers also had infants with lower scores across various developmental domains. The current study has many strengths including its focus on neurodevelopmental outcomes during infancy, an understudied developmental period, and the use of a novel analytical method to control for the effects of co-occurring metals while examining the effect of each metal on neurodevelopmental outcomes. Yet, future examination of how the effects of prenatal exposure on neurodevelopmental outcomes unfold over time while considering all potential interactions among metals and micronutrients is warranted. MDPI 2021-12-31 /pmc/articles/PMC8744969/ /pubmed/35010683 http://dx.doi.org/10.3390/ijerph19010425 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nozadi, Sara S.
Li, Li
Luo, Li
MacKenzie, Debra
Erdei, Esther
Du, Ruofei
Roman, Carolyn W.
Hoover, Joseph
O’Donald, Elena
Burnette, Courtney
Lewis, Johnnye
Prenatal Metal Exposures and Infants’ Developmental Outcomes in a Navajo Population
title Prenatal Metal Exposures and Infants’ Developmental Outcomes in a Navajo Population
title_full Prenatal Metal Exposures and Infants’ Developmental Outcomes in a Navajo Population
title_fullStr Prenatal Metal Exposures and Infants’ Developmental Outcomes in a Navajo Population
title_full_unstemmed Prenatal Metal Exposures and Infants’ Developmental Outcomes in a Navajo Population
title_short Prenatal Metal Exposures and Infants’ Developmental Outcomes in a Navajo Population
title_sort prenatal metal exposures and infants’ developmental outcomes in a navajo population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744969/
https://www.ncbi.nlm.nih.gov/pubmed/35010683
http://dx.doi.org/10.3390/ijerph19010425
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