Cargando…

Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19

Right ventricular (RV) and left ventricular (LV) dysfunction is common in a significant number of hospitalized coronavirus disease 2019 (COVID-19) patients. This study was conducted to assess whether the improved mitochondrial bioenergetics by cardiometabolic drug meldonium can attenuate the develop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vilskersts, Reinis, Kigitovica, Dana, Korzh, Stanislava, Videja, Melita, Vilks, Karlis, Cirule, Helena, Skride, Andris, Makrecka-Kuka, Marina, Liepinsh, Edgars, Dambrova, Maija
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744985/ https://www.ncbi.nlm.nih.gov/pubmed/35008470 http://dx.doi.org/10.3390/ijms23010045

Ejemplares similares

Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure
por: Videja, Melita, et al.
Publicado: (2021)

Rats with congenital hydronephrosis show increased susceptibility to renal ischemia‐reperfusion injury
por: Vilskersts, Reinis, et al.
Publicado: (2020)

Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia
por: Makrecka‐Kuka, Marina, et al.
Publicado: (2020)

Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats
por: Kuka, Janis, et al.
Publicado: (2021)

Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism
por: Vilks, Karlis, et al.
Publicado: (2021)

Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice
por: Kuka, Janis, et al.
Publicado: (2020)

Data on cardiac and vascular functionality in ex vivo and in vivo models following acute administration of trimethylamine N-oxide
por: Videja, Melita, et al.
Publicado: (2023)

Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues
por: Makrecka-Kuka, Marina, et al.
Publicado: (2017)

Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity
por: Makarova, Elina, et al.
Publicado: (2019)

Low‐intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults
por: Liepinsh, Edgars, et al.
Publicado: (2020)

Heart-Type Fatty Acid Binding Protein Binds Long-Chain Acylcarnitines and Protects against Lipotoxicity
por: Zelencova-Gopejenko, Diana, et al.
Publicado: (2023)

Pharmacological activation of PPARβ/δ preserves mitochondrial respiratory function in ischemia/reperfusion via stimulation of fatty acid oxidation-linked respiration and PGC-1α/NRF-1 signaling
por: Papatheodorou, Ioanna, et al.
Publicado: (2022)

Fasting-Mimicking Diet Reduces Trimethylamine N-Oxide Levels and Improves Serum Biochemical Parameters in Healthy Volunteers
por: Videja, Melita, et al.
Publicado: (2022)

Excretion of the Polymyxin Derivative NAB739 in Murine Urine
por: Vaara, Martti, et al.
Publicado: (2020)

The brain acylcarnitine profile depends on nutritional state
por: Svalbe, Baiba, et al.
Publicado: (2015)

Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production
por: Makrecka-Kuka, Marina, et al.
Publicado: (2020)

Novel positive allosteric modulators of sigma-1 receptor
por: Vavers, Edijs, et al.
Publicado: (2015)

Ambrisentan-induced severe asymptomatic thrombocytopenia
por: Kigitovica, Dana, et al.
Publicado: (2020)

Baseline Clinical Characteristics and Incidence of Chronic Thromboembolic Pulmonary Hypertension Patients in Latvia, 2019–2020
por: Kauliņš, Ričards, et al.
Publicado: (2023)

Mitochondrial-Protective Effects of R-Phenibut after Experimental Traumatic Brain Injury
por: Kupats, Einars, et al.
Publicado: (2020)

Knockout of Tmlhe in mice is not associated with autism spectrum disorder phenotypes or motor dysfunction despite low carnitine levels
por: Liepinsh, Edgars, et al.
Publicado: (2023)

Misuse of the metabolic modulator meldonium in sports
por: Lippi, Giuseppe, et al.
Publicado: (2017)

Antidepressive-like Behavior-Related Metabolomic Signatures of Sigma-1 Receptor Knockout Mice
por: Svalbe, Baiba, et al.
Publicado: (2022)

Meldonium determination in milk and meat through UHPLC-HRMS
por: Temerdashev, A., et al.
Publicado: (2020)

Venous Thromboembolism Recurrence in Latvian Population: Single University Hospital Data
por: Ģībietis, Valdis, et al.
Publicado: (2019)

The Effects of Meldonium on the Renal Acute Ischemia/Reperfusion Injury in Rats
por: Đurašević, Siniša, et al.
Publicado: (2019)

The effects of meldonium on the acute ischemia/reperfusion liver injury in rats
por: Đurašević, Siniša, et al.
Publicado: (2021)

High-Resolution Respirometry for Simultaneous Measurement of Oxygen and Hydrogen Peroxide Fluxes in Permeabilized Cells, Tissue Homogenate and Isolated Mitochondria
por: Makrecka-Kuka, Marina, et al.
Publicado: (2015)

Investigation of Antibacterial and Antiinflammatory Activities of Proanthocyanidins from Pelargonium sidoides DC Root Extract
por: Jekabsone, Aiste, et al.
Publicado: (2019)

Insights into the pharmacodynamics and pharmacokinetics of meldonium after exposure to acute high altitude
por: Liu, Fengying, et al.
Publicado: (2023)

Chronic Thromboembolic Pulmonary Hypertension Mimicking Acute Pulmonary Embolism: A Case Report
por: Kaulins, Ricards, et al.
Publicado: (2021)

Assessment of Iodine and Selenium Nutritional Status in Women of Reproductive Age in Latvia
por: Veisa, Vija, et al.
Publicado: (2021)

Editorial: Lipotoxicity, mitotoxicity, and drug targets
por: Krako Jakovljevic, Nina, et al.
Publicado: (2023)

The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats
por: Đurašević, Siniša, et al.
Publicado: (2021)

The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats
por: Đurašević, Siniša, et al.
Publicado: (2022)

Olaparib Conjugates with Selenopheno[3,2-c]quinolinone Inhibit PARP1 and Reverse ABCB1-Related Multidrug Resistance
por: Makrecka-Kuka, Marina, et al.
Publicado: (2022)

Normalization of heart rate variability with taurine and meldonium complex in post-infarction patients with type 2 diabetes mellitus
por: Belikova, Juliia, et al.
Publicado: (2019)

Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis
por: Wang, Daohui, et al.
Publicado: (2022)

Meldonium Inhibits Cell Motility and Wound-Healing in Trabecular Meshwork Cells and Scleral Fibroblasts: Possible Applications in Glaucoma
por: Minnelli, Cristina, et al.
Publicado: (2023)

The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats
por: Allen, Mitchell E., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7cre1ckuberpjgkbgl68j20akh