Cargando…

Targeting MAPK/NF-κB Pathways in Anti-Inflammatory Potential of Rutaecarpine: Impact on Src/FAK-Mediated Macrophage Migration

Studies have discovered that different extracts of Evodia rutaecarpa and its phytochemicals show a variety of biological activities associated with inflammation. Although rutaecarpine, an alkaloid isolated from the unripe fruit of E. rutaecarpa, has been exposed to have anti-inflammatory properties,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jayakumar, Thanasekaran, Lin, Kao-Chang, Chang, Chao-Chien, Hsia, Chih-Wei, Manubolu, Manjunath, Huang, Wei-Chieh, Sheu, Joen-Rong, Hsia, Chih-Hsuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745017/ https://www.ncbi.nlm.nih.gov/pubmed/35008520 http://dx.doi.org/10.3390/ijms23010092

Ejemplares similares

Anti-Inflammatory Mechanism of An Alkaloid Rutaecarpine in LTA-Stimulated RAW 264.7 Cells: Pivotal Role on NF-κB and ERK/p38 Signaling Molecules
por: Jayakumar, Thanasekaran, et al.
Publicado: (2022)

Auraptene, a Monoterpene Coumarin, Inhibits LTA-Induced Inflammatory Mediators via Modulating NF-κB/MAPKs Signaling Pathways
por: Hsia, Chih-Hsuan, et al.
Publicado: (2021)

Corrigendum to “Auraptene, a Monoterpene Coumarin, Inhibits LTA-Induced Inflammatory Mediators via Modulating NF-κB/MAPKs Signaling Pathways”
por: Hsia, Chih-Hsuan, et al.
Publicado: (2022)

Columbianadin Dampens In Vitro Inflammatory Actions and Inhibits Liver Injury via Inhibition of NF-κB/MAPKs: Impacts on (∙)OH Radicals and HO-1 Expression
por: Jayakumar, Thanasekaran, et al.
Publicado: (2021)

Decreased Human Platelet Activation and Mouse Pulmonary Thrombosis by Rutaecarpine and Comparison of the Relative Effectiveness with BAY11-7082: Crucial Signals of p38-NF-κB
por: Huang, Wei-Chieh, et al.
Publicado: (2022)

Possible Molecular Targets of Novel Ruthenium Complexes in Antiplatelet Therapy
por: Jayakumar, Thanasekaran, et al.
Publicado: (2018)

Mechanisms of glabridin inhibition of integrin α(IIb)β(3) inside-out signals and NF-κB activation in human platelets
por: Huang, Wei-Chieh, et al.
Publicado: (2023)

Structure–Activity Relationship Study of Newly Synthesized Iridium-III Complexes as Potential Series for Treating Thrombotic Diseases
por: Yang, Chih-Hao, et al.
Publicado: (2018)

Mechanisms of TQ-6, a Novel Ruthenium-Derivative Compound, against Lipopolysaccharide-Induced In Vitro Macrophage Activation and Liver Injury in Experimental Mice: The Crucial Role of p38 MAPK and NF-κB Signaling
por: Hsia, Chih-Hsuan, et al.
Publicado: (2018)

Activation of Nrf2 by Esculetin Mitigates Inflammatory Responses through Suppression of NF-κB Signaling Cascade in RAW 264.7 Cells
por: Jayakumar, Thanasekaran, et al.
Publicado: (2022)

Synthetic Ruthenium Complex TQ-6 Potently Recovers Cerebral Ischemic Stroke: Attenuation of Microglia and Platelet Activation
por: Hsia, Chih-Hsuan, et al.
Publicado: (2020)

Esculetin, a Coumarin Derivative, Prevents Thrombosis: Inhibitory Signaling on PLCγ2–PKC–AKT Activation in Human Platelets
por: Hsia, Chih-Wei, et al.
Publicado: (2019)

Myricetin as a promising inhibitor of platelet fibrinogen receptor in humans
por: Chang, Yi, et al.
Publicado: (2023)

Rutaecarpine, an Alkaloid from Evodia rutaecarpa, Can Prevent Platelet Activation in Humans and Reduce Microvascular Thrombosis in Mice: Crucial Role of the PI3K/Akt/GSK3β Signal Axis through a Cyclic Nucleotides/VASP—Independent Mechanism
por: Huang, Chun-Jen, et al.
Publicado: (2021)

Modulation of human platelet activation and in vivo vascular thrombosis by columbianadin: regulation by integrin α(IIb)β(3) inside-out but not outside-in signals
por: Hou, Shaw-Min, et al.
Publicado: (2020)

Structure-Antiplatelet Activity Relationships of Novel Ruthenium (II) Complexes: Investigation of Its Molecular Targets
por: Hsia, Chih-Hsuan, et al.
Publicado: (2018)

Glabridin, a Bioactive Flavonoid from Licorice, Effectively Inhibits Platelet Activation in Humans and Mice
por: Chung, Chi-Li, et al.
Publicado: (2022)

Suppression of Human Platelet Activation via Integrin α(IIb)β(3) Outside-In Independent Signal and Reduction of the Mortality in Pulmonary Thrombosis by Auraptene
por: Hsia, Chih-Wei, et al.
Publicado: (2019)

Novel iridium (III)-derived organometallic compound for the inhibition of human platelet activation
por: Shyu, Kou-Gi, et al.
Publicado: (2018)

Novel iridium (III)-derived organometallic compound for the inhibition of human platelet activation
por: Shyu, Kou-Gi, et al.
Publicado: (2019)

A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies
por: Hsia, Chih-Hsuan, et al.
Publicado: (2017)

Author Correction: A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies
por: Hsia, Chih-Hsuan, et al.
Publicado: (2020)

Regulation of Human Platelet Activation and Prevention of Arterial Thrombosis in Mice by Auraptene through Inhibition of NF-κB Pathway
por: Hsia, Chih-Wei, et al.
Publicado: (2020)

New Therapeutic Agent against Arterial Thrombosis: An Iridium(III)-Derived Organometallic Compound
por: Hsia, Chih-Wei, et al.
Publicado: (2017)

A Critical Period for the Development of Schizophrenia-Like Pathology by Aberrant Postnatal Neurogenesis
por: Sheu, Joen-Rong, et al.
Publicado: (2019)

Antiplatelet Activity of a Newly Synthesized Novel Ruthenium (II): A Potential Role for Akt/JNK Signaling
por: Khamrang, Themmila, et al.
Publicado: (2017)

Ketamine, a Clinically Used Anesthetic, Inhibits Vascular Smooth Muscle Cell Proliferation via PP2A-Activated PI3K/Akt/ERK Inhibition
por: Chang, Yi, et al.
Publicado: (2017)

Novel Therapeutic Agent against Platelet Activation In Vitro and Arterial Thrombosis In Vivo by Morin Hydrate
por: Hsia, Chih-Wei, et al.
Publicado: (2018)

The Antithrombotic Agent Pterostilbene Interferes with Integrin α(IIb)β(3)-Mediated Inside-Out and Outside-In Signals in Human Platelets
por: Huang, Wei-Chieh, et al.
Publicado: (2021)

Hinokitiol Inhibits Migration of A549 Lung Cancer Cells via Suppression of MMPs and Induction of Antioxidant Enzymes and Apoptosis
por: Jayakumar, Thanasekaran, et al.
Publicado: (2018)

Multi-Targeting Andrographolide, a Novel NF-κB Inhibitor, as a Potential Therapeutic Agent for Stroke
por: Yang, Chih-Hao, et al.
Publicado: (2017)

Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation
por: Shyu, Ren-Shi, et al.
Publicado: (2018)

Norcantharidin, a clinical used chemotherapeutic agent, acts as a powerful inhibitor by interfering with fibrinogen–integrin α(II) (b)β(3) binding in human platelets
por: Hsia, Chih‐Hsuan, et al.
Publicado: (2018)

A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice
por: Sheu, Joen-Rong, et al.
Publicado: (2017)

Author Correction: A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice
por: Sheu, Joen-Rong, et al.
Publicado: (2020)

Molecular Targets of Natural Products for Chondroprotection in Destructive Joint Diseases
por: Jayakumar, Thanasekaran, et al.
Publicado: (2020)

Arecoline Promotes Migration of A549 Lung Cancer Cells through Activating the EGFR/Src/FAK Pathway
por: Chang, Chih-Hsiang, et al.
Publicado: (2019)

Progress in the Studies on Rutaecarpine
por: Lee, Seung Ho, et al.
Publicado: (2008)

Protective Effects of Ammannia baccifera Against CCl(4)-Induced Oxidative Stress in Rats
por: Goodla, Lavanya, et al.
Publicado: (2019)

Astaxanthin, a Carotenoid, Stimulates Immune Responses by Enhancing IFN-γ and IL-2 Secretion in Primary Cultured Lymphocytes in Vitro and ex Vivo
por: Lin, Kuan-Hung, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_a13rcq4am8ai88th5isg7ngcvi