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Role of Biomarkers as Prognostic Factors in Acute Peripheral Facial Palsy

Acute peripheral facial palsy (APFP), including Bell’s palsy and Ramsay Hunt syndrome, is a disease that affects daily life through facial motor dysfunction, causing psychological problems. Various tests to evaluate prognosis have been studied; however, there are no validated predictive biomarkers t...

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Autores principales: Kim, Tae Hoon, Yeo, Seung Geun, Byun, Jae Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745072/
https://www.ncbi.nlm.nih.gov/pubmed/35008742
http://dx.doi.org/10.3390/ijms23010307
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author Kim, Tae Hoon
Yeo, Seung Geun
Byun, Jae Yong
author_facet Kim, Tae Hoon
Yeo, Seung Geun
Byun, Jae Yong
author_sort Kim, Tae Hoon
collection PubMed
description Acute peripheral facial palsy (APFP), including Bell’s palsy and Ramsay Hunt syndrome, is a disease that affects daily life through facial motor dysfunction, causing psychological problems. Various tests to evaluate prognosis have been studied; however, there are no validated predictive biomarkers to guide clinical decision making. Therefore, specific biomarkers that respond to treatment are required to understand prognostic outcomes. In this review, we discuss existing literature regarding the role of APFP biomarkers in prognosis and recovery. We searched the PubMed, EMBASE, and Cochrane Library databases for relevant papers. Our screening identified relevant studies and biomarkers correlating with the identification of predictive biomarkers. Only studies published between January 2000 and October 2021 were included. Our search identified 5835 abstracts, of which 35 were selected. All biomarker samples were obtained from blood and were used in the evaluation of disease severity and prognosis associated with recovery. These biomarkers have been effective prognostic or predictive factors under various conditions. Finally, we classified them into five categories. There is no consensus in the literature on the correlation between outcomes and prognostic factors for APFP. Furthermore, the correlation between hematologic laboratory values and APFP prognosis remains unclear. However, it is important to identify new methods for improving the accuracy of facial paralysis prognosis prediction. Therefore, we systematically evaluated prognostic and potentially predictive APFP biomarkers. Unfortunately, a predictive biomarker validating APFP prognosis remains unknown. More prospective studies are required to reveal and identify promising biomarkers providing accurate prognosis.
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spelling pubmed-87450722022-01-11 Role of Biomarkers as Prognostic Factors in Acute Peripheral Facial Palsy Kim, Tae Hoon Yeo, Seung Geun Byun, Jae Yong Int J Mol Sci Review Acute peripheral facial palsy (APFP), including Bell’s palsy and Ramsay Hunt syndrome, is a disease that affects daily life through facial motor dysfunction, causing psychological problems. Various tests to evaluate prognosis have been studied; however, there are no validated predictive biomarkers to guide clinical decision making. Therefore, specific biomarkers that respond to treatment are required to understand prognostic outcomes. In this review, we discuss existing literature regarding the role of APFP biomarkers in prognosis and recovery. We searched the PubMed, EMBASE, and Cochrane Library databases for relevant papers. Our screening identified relevant studies and biomarkers correlating with the identification of predictive biomarkers. Only studies published between January 2000 and October 2021 were included. Our search identified 5835 abstracts, of which 35 were selected. All biomarker samples were obtained from blood and were used in the evaluation of disease severity and prognosis associated with recovery. These biomarkers have been effective prognostic or predictive factors under various conditions. Finally, we classified them into five categories. There is no consensus in the literature on the correlation between outcomes and prognostic factors for APFP. Furthermore, the correlation between hematologic laboratory values and APFP prognosis remains unclear. However, it is important to identify new methods for improving the accuracy of facial paralysis prognosis prediction. Therefore, we systematically evaluated prognostic and potentially predictive APFP biomarkers. Unfortunately, a predictive biomarker validating APFP prognosis remains unknown. More prospective studies are required to reveal and identify promising biomarkers providing accurate prognosis. MDPI 2021-12-28 /pmc/articles/PMC8745072/ /pubmed/35008742 http://dx.doi.org/10.3390/ijms23010307 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kim, Tae Hoon
Yeo, Seung Geun
Byun, Jae Yong
Role of Biomarkers as Prognostic Factors in Acute Peripheral Facial Palsy
title Role of Biomarkers as Prognostic Factors in Acute Peripheral Facial Palsy
title_full Role of Biomarkers as Prognostic Factors in Acute Peripheral Facial Palsy
title_fullStr Role of Biomarkers as Prognostic Factors in Acute Peripheral Facial Palsy
title_full_unstemmed Role of Biomarkers as Prognostic Factors in Acute Peripheral Facial Palsy
title_short Role of Biomarkers as Prognostic Factors in Acute Peripheral Facial Palsy
title_sort role of biomarkers as prognostic factors in acute peripheral facial palsy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745072/
https://www.ncbi.nlm.nih.gov/pubmed/35008742
http://dx.doi.org/10.3390/ijms23010307
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