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Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake

Ageing, in a natural way, leads to the gradual worsening of the functional capacity of all systems and, eventually, to death. This process is strongly associated with higher metabolic and oxidative stress, low-grade inflammation, accumulation of DNA mutations and increased levels of related damage....

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Autores principales: Rysz, Jacek, Franczyk, Beata, Rysz-Górzyńska, Magdalena, Gluba-Brzózka, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745076/
https://www.ncbi.nlm.nih.gov/pubmed/35008609
http://dx.doi.org/10.3390/ijms23010183
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author Rysz, Jacek
Franczyk, Beata
Rysz-Górzyńska, Magdalena
Gluba-Brzózka, Anna
author_facet Rysz, Jacek
Franczyk, Beata
Rysz-Górzyńska, Magdalena
Gluba-Brzózka, Anna
author_sort Rysz, Jacek
collection PubMed
description Ageing, in a natural way, leads to the gradual worsening of the functional capacity of all systems and, eventually, to death. This process is strongly associated with higher metabolic and oxidative stress, low-grade inflammation, accumulation of DNA mutations and increased levels of related damage. Detrimental changes that accumulate in body cells and tissues with time raise the vulnerability to environmental challenges and enhance the risk of major chronic diseases and mortality. There are several theses concerning the mechanisms of ageing: genetic, free radical telomerase, mitochondrial decline, metabolic damage, cellular senescence, neuroendocrine theory, Hay-flick limit and membrane theories, cellular death as well as the accumulation of toxic and non-toxic garbage. Moreover, ageing is associated with structural changes within the myocardium, cardiac conduction system, the endocardium as well as the vasculature. With time, the cardiac structures lose elasticity, and fibrotic changes occur in the heart valves. Ageing is also associated with a higher risk of atherosclerosis. The results of studies suggest that some natural compounds may slow down this process and protect against age-related diseases. Animal studies imply that some of them may prolong the lifespan; however, this trend is not so obvious in humans.
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spelling pubmed-87450762022-01-11 Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake Rysz, Jacek Franczyk, Beata Rysz-Górzyńska, Magdalena Gluba-Brzózka, Anna Int J Mol Sci Review Ageing, in a natural way, leads to the gradual worsening of the functional capacity of all systems and, eventually, to death. This process is strongly associated with higher metabolic and oxidative stress, low-grade inflammation, accumulation of DNA mutations and increased levels of related damage. Detrimental changes that accumulate in body cells and tissues with time raise the vulnerability to environmental challenges and enhance the risk of major chronic diseases and mortality. There are several theses concerning the mechanisms of ageing: genetic, free radical telomerase, mitochondrial decline, metabolic damage, cellular senescence, neuroendocrine theory, Hay-flick limit and membrane theories, cellular death as well as the accumulation of toxic and non-toxic garbage. Moreover, ageing is associated with structural changes within the myocardium, cardiac conduction system, the endocardium as well as the vasculature. With time, the cardiac structures lose elasticity, and fibrotic changes occur in the heart valves. Ageing is also associated with a higher risk of atherosclerosis. The results of studies suggest that some natural compounds may slow down this process and protect against age-related diseases. Animal studies imply that some of them may prolong the lifespan; however, this trend is not so obvious in humans. MDPI 2021-12-24 /pmc/articles/PMC8745076/ /pubmed/35008609 http://dx.doi.org/10.3390/ijms23010183 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rysz, Jacek
Franczyk, Beata
Rysz-Górzyńska, Magdalena
Gluba-Brzózka, Anna
Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake
title Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake
title_full Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake
title_fullStr Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake
title_full_unstemmed Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake
title_short Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake
title_sort ageing, age-related cardiovascular risk and the beneficial role of natural components intake
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745076/
https://www.ncbi.nlm.nih.gov/pubmed/35008609
http://dx.doi.org/10.3390/ijms23010183
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