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The Impact of Iron Chelators on the Biology of Cancer Stem Cells

Neoplastic diseases are still a major medical challenge, requiring a constant search for new therapeutic options. A serious problem of many cancers is resistance to anticancer drugs and disease progression in metastases or local recurrence. These characteristics of cancer cells may be related to the...

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Autores principales: Szymonik, Julia, Wala, Kamila, Górnicki, Tomasz, Saczko, Jolanta, Pencakowski, Bartosz, Kulbacka, Julita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745085/
https://www.ncbi.nlm.nih.gov/pubmed/35008527
http://dx.doi.org/10.3390/ijms23010089
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author Szymonik, Julia
Wala, Kamila
Górnicki, Tomasz
Saczko, Jolanta
Pencakowski, Bartosz
Kulbacka, Julita
author_facet Szymonik, Julia
Wala, Kamila
Górnicki, Tomasz
Saczko, Jolanta
Pencakowski, Bartosz
Kulbacka, Julita
author_sort Szymonik, Julia
collection PubMed
description Neoplastic diseases are still a major medical challenge, requiring a constant search for new therapeutic options. A serious problem of many cancers is resistance to anticancer drugs and disease progression in metastases or local recurrence. These characteristics of cancer cells may be related to the specific properties of cancer stem cells (CSC). CSCs are involved in inhibiting cells’ maturation, which is essential for maintaining their self-renewal capacity and pluripotency. They show increased expression of transcription factor proteins, which were defined as stemness-related markers. This group of proteins includes OCT4, SOX2, KLF4, Nanog, and SALL4. It has been noticed that the metabolism of cancer cells is changed, and the demand for iron is significantly increased. Iron chelators have been proven to have antitumor activity and influence the expression of stemness-related markers, thus reducing chemoresistance and the risk of tumor cell progression. This prompts further investigation of these agents as promising anticancer novel drugs. The article presents the characteristics of stemness markers and their influence on the development and course of neoplastic disease. Available iron chelators were also described, and their effects on cancer cells and expression of stemness-related markers were analyzed.
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spelling pubmed-87450852022-01-11 The Impact of Iron Chelators on the Biology of Cancer Stem Cells Szymonik, Julia Wala, Kamila Górnicki, Tomasz Saczko, Jolanta Pencakowski, Bartosz Kulbacka, Julita Int J Mol Sci Review Neoplastic diseases are still a major medical challenge, requiring a constant search for new therapeutic options. A serious problem of many cancers is resistance to anticancer drugs and disease progression in metastases or local recurrence. These characteristics of cancer cells may be related to the specific properties of cancer stem cells (CSC). CSCs are involved in inhibiting cells’ maturation, which is essential for maintaining their self-renewal capacity and pluripotency. They show increased expression of transcription factor proteins, which were defined as stemness-related markers. This group of proteins includes OCT4, SOX2, KLF4, Nanog, and SALL4. It has been noticed that the metabolism of cancer cells is changed, and the demand for iron is significantly increased. Iron chelators have been proven to have antitumor activity and influence the expression of stemness-related markers, thus reducing chemoresistance and the risk of tumor cell progression. This prompts further investigation of these agents as promising anticancer novel drugs. The article presents the characteristics of stemness markers and their influence on the development and course of neoplastic disease. Available iron chelators were also described, and their effects on cancer cells and expression of stemness-related markers were analyzed. MDPI 2021-12-22 /pmc/articles/PMC8745085/ /pubmed/35008527 http://dx.doi.org/10.3390/ijms23010089 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Szymonik, Julia
Wala, Kamila
Górnicki, Tomasz
Saczko, Jolanta
Pencakowski, Bartosz
Kulbacka, Julita
The Impact of Iron Chelators on the Biology of Cancer Stem Cells
title The Impact of Iron Chelators on the Biology of Cancer Stem Cells
title_full The Impact of Iron Chelators on the Biology of Cancer Stem Cells
title_fullStr The Impact of Iron Chelators on the Biology of Cancer Stem Cells
title_full_unstemmed The Impact of Iron Chelators on the Biology of Cancer Stem Cells
title_short The Impact of Iron Chelators on the Biology of Cancer Stem Cells
title_sort impact of iron chelators on the biology of cancer stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745085/
https://www.ncbi.nlm.nih.gov/pubmed/35008527
http://dx.doi.org/10.3390/ijms23010089
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