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The Role of Altered Mitochondrial Metabolism in Thyroid Cancer Development and Mitochondria-Targeted Thyroid Cancer Treatment
Thyroid cancer (TC) is the most common type of endocrine malignancy. Tumour formation, progression, and metastasis greatly depend on the efficacy of mitochondria—primarily, the regulation of mitochondria-mediated apoptosis, Ca(2+) homeostasis, dynamics, energy production, and associated reactive oxy...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745127/ https://www.ncbi.nlm.nih.gov/pubmed/35008887 http://dx.doi.org/10.3390/ijms23010460 |
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author | Dabravolski, Siarhei A. Nikiforov, Nikita G. Zhuravlev, Alexander D. Orekhov, Nikolay A. Mikhaleva, Liudmila M. Orekhov, Alexander N. |
author_facet | Dabravolski, Siarhei A. Nikiforov, Nikita G. Zhuravlev, Alexander D. Orekhov, Nikolay A. Mikhaleva, Liudmila M. Orekhov, Alexander N. |
author_sort | Dabravolski, Siarhei A. |
collection | PubMed |
description | Thyroid cancer (TC) is the most common type of endocrine malignancy. Tumour formation, progression, and metastasis greatly depend on the efficacy of mitochondria—primarily, the regulation of mitochondria-mediated apoptosis, Ca(2+) homeostasis, dynamics, energy production, and associated reactive oxygen species generation. Recent studies have successfully confirmed the mitochondrial aetiology of thyroid carcinogenesis. In this review, we focus on the recent progress in understanding the molecular mechanisms of thyroid cancer relating to altered mitochondrial metabolism. We also discuss the repurposing of known drugs and the induction of mitochondria-mediated apoptosis as a new trend in the development of anti-TC therapy. |
format | Online Article Text |
id | pubmed-8745127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87451272022-01-11 The Role of Altered Mitochondrial Metabolism in Thyroid Cancer Development and Mitochondria-Targeted Thyroid Cancer Treatment Dabravolski, Siarhei A. Nikiforov, Nikita G. Zhuravlev, Alexander D. Orekhov, Nikolay A. Mikhaleva, Liudmila M. Orekhov, Alexander N. Int J Mol Sci Review Thyroid cancer (TC) is the most common type of endocrine malignancy. Tumour formation, progression, and metastasis greatly depend on the efficacy of mitochondria—primarily, the regulation of mitochondria-mediated apoptosis, Ca(2+) homeostasis, dynamics, energy production, and associated reactive oxygen species generation. Recent studies have successfully confirmed the mitochondrial aetiology of thyroid carcinogenesis. In this review, we focus on the recent progress in understanding the molecular mechanisms of thyroid cancer relating to altered mitochondrial metabolism. We also discuss the repurposing of known drugs and the induction of mitochondria-mediated apoptosis as a new trend in the development of anti-TC therapy. MDPI 2021-12-31 /pmc/articles/PMC8745127/ /pubmed/35008887 http://dx.doi.org/10.3390/ijms23010460 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dabravolski, Siarhei A. Nikiforov, Nikita G. Zhuravlev, Alexander D. Orekhov, Nikolay A. Mikhaleva, Liudmila M. Orekhov, Alexander N. The Role of Altered Mitochondrial Metabolism in Thyroid Cancer Development and Mitochondria-Targeted Thyroid Cancer Treatment |
title | The Role of Altered Mitochondrial Metabolism in Thyroid Cancer Development and Mitochondria-Targeted Thyroid Cancer Treatment |
title_full | The Role of Altered Mitochondrial Metabolism in Thyroid Cancer Development and Mitochondria-Targeted Thyroid Cancer Treatment |
title_fullStr | The Role of Altered Mitochondrial Metabolism in Thyroid Cancer Development and Mitochondria-Targeted Thyroid Cancer Treatment |
title_full_unstemmed | The Role of Altered Mitochondrial Metabolism in Thyroid Cancer Development and Mitochondria-Targeted Thyroid Cancer Treatment |
title_short | The Role of Altered Mitochondrial Metabolism in Thyroid Cancer Development and Mitochondria-Targeted Thyroid Cancer Treatment |
title_sort | role of altered mitochondrial metabolism in thyroid cancer development and mitochondria-targeted thyroid cancer treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745127/ https://www.ncbi.nlm.nih.gov/pubmed/35008887 http://dx.doi.org/10.3390/ijms23010460 |
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