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Flavonoids Seen through the Energy Perspective

In all life forms, opposing forces provide the energy that flows through networks in an organism, which fuels life. In this concept, health is the ability of an organism to maintain the balance between these opposing forces, which creates resilience, and a deranged flow of energy is the basis for di...

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Autores principales: Li, Zhengwen, Zhang, Ming, Haenen, Guido R. M. M., Vervoort, Lily, Moalin, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745170/
https://www.ncbi.nlm.nih.gov/pubmed/35008613
http://dx.doi.org/10.3390/ijms23010187
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author Li, Zhengwen
Zhang, Ming
Haenen, Guido R. M. M.
Vervoort, Lily
Moalin, Mohamed
author_facet Li, Zhengwen
Zhang, Ming
Haenen, Guido R. M. M.
Vervoort, Lily
Moalin, Mohamed
author_sort Li, Zhengwen
collection PubMed
description In all life forms, opposing forces provide the energy that flows through networks in an organism, which fuels life. In this concept, health is the ability of an organism to maintain the balance between these opposing forces, which creates resilience, and a deranged flow of energy is the basis for diseases. Treatment should focus on adjusting the deranged flow of energy, e.g., by the redox modulating activity of antioxidants. A major group of antioxidants is formed by flavonoids, a group of polyphenolic compounds abundantly present in our diet. The objective here is to review how the redox modulation by flavonoids fits in the various concepts on the mode of action of bioactive compounds, so we can ‘see’ where there is overlap and where the missing links are. Based on this fundament, we should choose our research path aiming to ‘understand’ the redox modulating profile of specific flavonoids, so we can ultimately rationally apply the redox modulating power of flavonoids to improve our health.
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spelling pubmed-87451702022-01-11 Flavonoids Seen through the Energy Perspective Li, Zhengwen Zhang, Ming Haenen, Guido R. M. M. Vervoort, Lily Moalin, Mohamed Int J Mol Sci Review In all life forms, opposing forces provide the energy that flows through networks in an organism, which fuels life. In this concept, health is the ability of an organism to maintain the balance between these opposing forces, which creates resilience, and a deranged flow of energy is the basis for diseases. Treatment should focus on adjusting the deranged flow of energy, e.g., by the redox modulating activity of antioxidants. A major group of antioxidants is formed by flavonoids, a group of polyphenolic compounds abundantly present in our diet. The objective here is to review how the redox modulation by flavonoids fits in the various concepts on the mode of action of bioactive compounds, so we can ‘see’ where there is overlap and where the missing links are. Based on this fundament, we should choose our research path aiming to ‘understand’ the redox modulating profile of specific flavonoids, so we can ultimately rationally apply the redox modulating power of flavonoids to improve our health. MDPI 2021-12-24 /pmc/articles/PMC8745170/ /pubmed/35008613 http://dx.doi.org/10.3390/ijms23010187 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Zhengwen
Zhang, Ming
Haenen, Guido R. M. M.
Vervoort, Lily
Moalin, Mohamed
Flavonoids Seen through the Energy Perspective
title Flavonoids Seen through the Energy Perspective
title_full Flavonoids Seen through the Energy Perspective
title_fullStr Flavonoids Seen through the Energy Perspective
title_full_unstemmed Flavonoids Seen through the Energy Perspective
title_short Flavonoids Seen through the Energy Perspective
title_sort flavonoids seen through the energy perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745170/
https://www.ncbi.nlm.nih.gov/pubmed/35008613
http://dx.doi.org/10.3390/ijms23010187
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AT vervoortlily flavonoidsseenthroughtheenergyperspective
AT moalinmohamed flavonoidsseenthroughtheenergyperspective