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Flavonoids Seen through the Energy Perspective
In all life forms, opposing forces provide the energy that flows through networks in an organism, which fuels life. In this concept, health is the ability of an organism to maintain the balance between these opposing forces, which creates resilience, and a deranged flow of energy is the basis for di...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745170/ https://www.ncbi.nlm.nih.gov/pubmed/35008613 http://dx.doi.org/10.3390/ijms23010187 |
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author | Li, Zhengwen Zhang, Ming Haenen, Guido R. M. M. Vervoort, Lily Moalin, Mohamed |
author_facet | Li, Zhengwen Zhang, Ming Haenen, Guido R. M. M. Vervoort, Lily Moalin, Mohamed |
author_sort | Li, Zhengwen |
collection | PubMed |
description | In all life forms, opposing forces provide the energy that flows through networks in an organism, which fuels life. In this concept, health is the ability of an organism to maintain the balance between these opposing forces, which creates resilience, and a deranged flow of energy is the basis for diseases. Treatment should focus on adjusting the deranged flow of energy, e.g., by the redox modulating activity of antioxidants. A major group of antioxidants is formed by flavonoids, a group of polyphenolic compounds abundantly present in our diet. The objective here is to review how the redox modulation by flavonoids fits in the various concepts on the mode of action of bioactive compounds, so we can ‘see’ where there is overlap and where the missing links are. Based on this fundament, we should choose our research path aiming to ‘understand’ the redox modulating profile of specific flavonoids, so we can ultimately rationally apply the redox modulating power of flavonoids to improve our health. |
format | Online Article Text |
id | pubmed-8745170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87451702022-01-11 Flavonoids Seen through the Energy Perspective Li, Zhengwen Zhang, Ming Haenen, Guido R. M. M. Vervoort, Lily Moalin, Mohamed Int J Mol Sci Review In all life forms, opposing forces provide the energy that flows through networks in an organism, which fuels life. In this concept, health is the ability of an organism to maintain the balance between these opposing forces, which creates resilience, and a deranged flow of energy is the basis for diseases. Treatment should focus on adjusting the deranged flow of energy, e.g., by the redox modulating activity of antioxidants. A major group of antioxidants is formed by flavonoids, a group of polyphenolic compounds abundantly present in our diet. The objective here is to review how the redox modulation by flavonoids fits in the various concepts on the mode of action of bioactive compounds, so we can ‘see’ where there is overlap and where the missing links are. Based on this fundament, we should choose our research path aiming to ‘understand’ the redox modulating profile of specific flavonoids, so we can ultimately rationally apply the redox modulating power of flavonoids to improve our health. MDPI 2021-12-24 /pmc/articles/PMC8745170/ /pubmed/35008613 http://dx.doi.org/10.3390/ijms23010187 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Zhengwen Zhang, Ming Haenen, Guido R. M. M. Vervoort, Lily Moalin, Mohamed Flavonoids Seen through the Energy Perspective |
title | Flavonoids Seen through the Energy Perspective |
title_full | Flavonoids Seen through the Energy Perspective |
title_fullStr | Flavonoids Seen through the Energy Perspective |
title_full_unstemmed | Flavonoids Seen through the Energy Perspective |
title_short | Flavonoids Seen through the Energy Perspective |
title_sort | flavonoids seen through the energy perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745170/ https://www.ncbi.nlm.nih.gov/pubmed/35008613 http://dx.doi.org/10.3390/ijms23010187 |
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