Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX

Among the twelve catalytically active carbonic anhydrase isozymes present in the human body, the CAIX is highly overexpressed in various solid tumors. The enzyme acidifies the tumor microenvironment enabling invasion and metastatic processes. Therefore, many attempts have been made to design chemica...

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Detalles Bibliográficos
Autores principales: Zakšauskas, Audrius, Čapkauskaitė, Edita, Paketurytė-Latvė, Vaida, Smirnov, Alexey, Leitans, Janis, Kazaks, Andris, Dvinskis, Elviss, Stančaitis, Laimonas, Mickevičiūtė, Aurelija, Jachno, Jelena, Jezepčikas, Linas, Linkuvienė, Vaida, Sakalauskas, Andrius, Manakova, Elena, Gražulis, Saulius, Matulienė, Jurgita, Tars, Kaspars, Matulis, Daumantas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745178/
https://www.ncbi.nlm.nih.gov/pubmed/35008553
http://dx.doi.org/10.3390/ijms23010130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745178/
https://www.ncbi.nlm.nih.gov/pubmed/35008553
http://dx.doi.org/10.3390/ijms23010130

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