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Survival of Women Previously Diagnosed of Melanoma with Subsequent Pregnancy: A Systematic Review and Meta-Analysis and a Single-Center Experience

Melanoma incidence has increased over the last few decades. How the prognosis of a previously diagnosed melanoma may be affected by a woman’s subsequent pregnancy has been debated in the literature since the 1950s, and the outcomes are essential to women who are melanoma survivors in their childbear...

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Autores principales: Martínez-Campayo, Nieves, Paradela de la Morena, Sabela, Pértega-Díaz, Sonia, Iglesias Pena, Luisa, Vihinen, Pia, Mattila, Kalle, Lens, Marko B., Tejera-Vaquerizo, Antonio, Fonseca, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745217/
https://www.ncbi.nlm.nih.gov/pubmed/35011822
http://dx.doi.org/10.3390/jcm11010083
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author Martínez-Campayo, Nieves
Paradela de la Morena, Sabela
Pértega-Díaz, Sonia
Iglesias Pena, Luisa
Vihinen, Pia
Mattila, Kalle
Lens, Marko B.
Tejera-Vaquerizo, Antonio
Fonseca, Eduardo
author_facet Martínez-Campayo, Nieves
Paradela de la Morena, Sabela
Pértega-Díaz, Sonia
Iglesias Pena, Luisa
Vihinen, Pia
Mattila, Kalle
Lens, Marko B.
Tejera-Vaquerizo, Antonio
Fonseca, Eduardo
author_sort Martínez-Campayo, Nieves
collection PubMed
description Melanoma incidence has increased over the last few decades. How the prognosis of a previously diagnosed melanoma may be affected by a woman’s subsequent pregnancy has been debated in the literature since the 1950s, and the outcomes are essential to women who are melanoma survivors in their childbearing years. The main objective of this systematic review is to improve the understanding of whether the course of melanoma in a woman may be altered by a subsequent pregnancy and to help clinicians’ diagnosis. Eligible studies for the systematic review were clinical trials, observational cohort studies and case-control studies that compared prognosis outcomes for non-pregnant patients with melanoma, or pregnant before melanoma diagnosis, versus pregnant patients after a diagnosis of melanoma. The search strategy yielded 1101 articles, of which 4 met the inclusion criteria for the systematic review. All the studies were retrospective non-randomised cohorts with patients with melanomas diagnosed before pregnancy. According to our findings, a subsequent pregnancy was not a significant influence on the outcome of a previous melanoma. However, given the small number of identified studies and the heterogeneous data included, it is recommended to approach these patients with caution, and counselling should be given by known prognostic factors. We also reviewed the medical records of 84 patients of childbearing age (35.8 ± 6.3 years, range 21–45 years) who were diagnosed with cutaneous invasive melanoma in our hospital between 2008 and 2018 (N = 724). Of these, 11 (13.1%) had a pregnancy after melanoma diagnosis (age at pregnancy: 35.6 ± 6.3 years). No statistical differences in outcome were detected.
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spelling pubmed-87452172022-01-11 Survival of Women Previously Diagnosed of Melanoma with Subsequent Pregnancy: A Systematic Review and Meta-Analysis and a Single-Center Experience Martínez-Campayo, Nieves Paradela de la Morena, Sabela Pértega-Díaz, Sonia Iglesias Pena, Luisa Vihinen, Pia Mattila, Kalle Lens, Marko B. Tejera-Vaquerizo, Antonio Fonseca, Eduardo J Clin Med Review Melanoma incidence has increased over the last few decades. How the prognosis of a previously diagnosed melanoma may be affected by a woman’s subsequent pregnancy has been debated in the literature since the 1950s, and the outcomes are essential to women who are melanoma survivors in their childbearing years. The main objective of this systematic review is to improve the understanding of whether the course of melanoma in a woman may be altered by a subsequent pregnancy and to help clinicians’ diagnosis. Eligible studies for the systematic review were clinical trials, observational cohort studies and case-control studies that compared prognosis outcomes for non-pregnant patients with melanoma, or pregnant before melanoma diagnosis, versus pregnant patients after a diagnosis of melanoma. The search strategy yielded 1101 articles, of which 4 met the inclusion criteria for the systematic review. All the studies were retrospective non-randomised cohorts with patients with melanomas diagnosed before pregnancy. According to our findings, a subsequent pregnancy was not a significant influence on the outcome of a previous melanoma. However, given the small number of identified studies and the heterogeneous data included, it is recommended to approach these patients with caution, and counselling should be given by known prognostic factors. We also reviewed the medical records of 84 patients of childbearing age (35.8 ± 6.3 years, range 21–45 years) who were diagnosed with cutaneous invasive melanoma in our hospital between 2008 and 2018 (N = 724). Of these, 11 (13.1%) had a pregnancy after melanoma diagnosis (age at pregnancy: 35.6 ± 6.3 years). No statistical differences in outcome were detected. MDPI 2021-12-24 /pmc/articles/PMC8745217/ /pubmed/35011822 http://dx.doi.org/10.3390/jcm11010083 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martínez-Campayo, Nieves
Paradela de la Morena, Sabela
Pértega-Díaz, Sonia
Iglesias Pena, Luisa
Vihinen, Pia
Mattila, Kalle
Lens, Marko B.
Tejera-Vaquerizo, Antonio
Fonseca, Eduardo
Survival of Women Previously Diagnosed of Melanoma with Subsequent Pregnancy: A Systematic Review and Meta-Analysis and a Single-Center Experience
title Survival of Women Previously Diagnosed of Melanoma with Subsequent Pregnancy: A Systematic Review and Meta-Analysis and a Single-Center Experience
title_full Survival of Women Previously Diagnosed of Melanoma with Subsequent Pregnancy: A Systematic Review and Meta-Analysis and a Single-Center Experience
title_fullStr Survival of Women Previously Diagnosed of Melanoma with Subsequent Pregnancy: A Systematic Review and Meta-Analysis and a Single-Center Experience
title_full_unstemmed Survival of Women Previously Diagnosed of Melanoma with Subsequent Pregnancy: A Systematic Review and Meta-Analysis and a Single-Center Experience
title_short Survival of Women Previously Diagnosed of Melanoma with Subsequent Pregnancy: A Systematic Review and Meta-Analysis and a Single-Center Experience
title_sort survival of women previously diagnosed of melanoma with subsequent pregnancy: a systematic review and meta-analysis and a single-center experience
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745217/
https://www.ncbi.nlm.nih.gov/pubmed/35011822
http://dx.doi.org/10.3390/jcm11010083
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