Macrophage Polarity and Disease Control

Macrophages are present in most human tissues and have very diverse functions. Activated macrophages are usually divided into two phenotypes, M1 macrophages and M2 macrophages, which are altered by various factors such as microorganisms, tissue microenvironment, and cytokine signals. Macrophage pola...

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Detalles Bibliográficos
Autores principales: Kadomoto, Suguru, Izumi, Kouji, Mizokami, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745226/
https://www.ncbi.nlm.nih.gov/pubmed/35008577
http://dx.doi.org/10.3390/ijms23010144
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author Kadomoto, Suguru
Izumi, Kouji
Mizokami, Atsushi
author_facet Kadomoto, Suguru
Izumi, Kouji
Mizokami, Atsushi
author_sort Kadomoto, Suguru
collection PubMed
description Macrophages are present in most human tissues and have very diverse functions. Activated macrophages are usually divided into two phenotypes, M1 macrophages and M2 macrophages, which are altered by various factors such as microorganisms, tissue microenvironment, and cytokine signals. Macrophage polarity is very important for infections, inflammatory diseases, and malignancies; its management can be key in the prevention and treatment of diseases. In this review, we assess the current state of knowledge on macrophage polarity and report on its prospects as a therapeutic target.
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spelling pubmed-87452262022-01-11 Macrophage Polarity and Disease Control Kadomoto, Suguru Izumi, Kouji Mizokami, Atsushi Int J Mol Sci Review Macrophages are present in most human tissues and have very diverse functions. Activated macrophages are usually divided into two phenotypes, M1 macrophages and M2 macrophages, which are altered by various factors such as microorganisms, tissue microenvironment, and cytokine signals. Macrophage polarity is very important for infections, inflammatory diseases, and malignancies; its management can be key in the prevention and treatment of diseases. In this review, we assess the current state of knowledge on macrophage polarity and report on its prospects as a therapeutic target. MDPI 2021-12-23 /pmc/articles/PMC8745226/ /pubmed/35008577 http://dx.doi.org/10.3390/ijms23010144 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kadomoto, Suguru
Izumi, Kouji
Mizokami, Atsushi
Macrophage Polarity and Disease Control
title Macrophage Polarity and Disease Control
title_full Macrophage Polarity and Disease Control
title_fullStr Macrophage Polarity and Disease Control
title_full_unstemmed Macrophage Polarity and Disease Control
title_short Macrophage Polarity and Disease Control
title_sort macrophage polarity and disease control
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745226/
https://www.ncbi.nlm.nih.gov/pubmed/35008577
http://dx.doi.org/10.3390/ijms23010144
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AT izumikouji macrophagepolarityanddiseasecontrol
AT mizokamiatsushi macrophagepolarityanddiseasecontrol

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