The Class I HDAC Inhibitor, MS-275, Prevents Oxaliplatin-Induced Chronic Neuropathy and Potentiates Its Antiproliferative Activity in Mice

Oxaliplatin, the first-line chemotherapeutic agent against colorectal cancer (CRC), induces peripheral neuropathies, which can lead to dose limitation and treatment discontinuation. Downregulation of potassium channels, which involves histone deacetylase (HDAC) activity, has been identified as an im...

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Detalles Bibliográficos
Autores principales: Lamoine, Sylvain, Cumenal, Mélissa, Barriere, David A., Pereira, Vanessa, Fereyrolles, Mathilde, Prival, Laëtitia, Barbier, Julie, Boudieu, Ludivine, Brasset, Emilie, Bertin, Benjamin, Renaud, Yoan, Miot-Noirault, Elisabeth, Civiale, Marie-Ange, Balayssac, David, Aissouni, Youssef, Eschalier, Alain, Busserolles, Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745279/
https://www.ncbi.nlm.nih.gov/pubmed/35008525
http://dx.doi.org/10.3390/ijms23010098

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