Cargando…

Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer’s Disease Proteinopathy

In this review, we summarize, inter alia, the protein and gene changes associated with Alzheimer’s disease and their role in post-ischemic hippocampal neurodegeneration. In the hippocampus, studies have revealed dysregulation of the genes for the amyloid protein precursor metabolism and tau protein...

Descripción completa

Detalles Bibliográficos
Autores principales: Pluta, Ryszard, Januszewski, Sławomir, Czuczwar, Stanisław J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745293/
https://www.ncbi.nlm.nih.gov/pubmed/35008731
http://dx.doi.org/10.3390/ijms23010306
_version_ 1784630310156107776
author Pluta, Ryszard
Januszewski, Sławomir
Czuczwar, Stanisław J.
author_facet Pluta, Ryszard
Januszewski, Sławomir
Czuczwar, Stanisław J.
author_sort Pluta, Ryszard
collection PubMed
description In this review, we summarize, inter alia, the protein and gene changes associated with Alzheimer’s disease and their role in post-ischemic hippocampal neurodegeneration. In the hippocampus, studies have revealed dysregulation of the genes for the amyloid protein precursor metabolism and tau protein that is identical in nature to Alzheimer’s disease. Data indicate that amyloid and tau protein, derived from brain tissue and blood due to increased permeability of the blood–brain barrier after ischemia, play a key role in post-ischemic neurodegeneration of the hippocampus, with concomitant development of full-blown dementia. Thus, the knowledge of new neurodegenerative mechanisms that cause neurodegeneration of the hippocampus after ischemia, resembling Alzheimer’s disease proteinopathy, will provide the most important therapeutic development goals to date.
format Online
Article
Text
id pubmed-8745293
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87452932022-01-11 Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer’s Disease Proteinopathy Pluta, Ryszard Januszewski, Sławomir Czuczwar, Stanisław J. Int J Mol Sci Review In this review, we summarize, inter alia, the protein and gene changes associated with Alzheimer’s disease and their role in post-ischemic hippocampal neurodegeneration. In the hippocampus, studies have revealed dysregulation of the genes for the amyloid protein precursor metabolism and tau protein that is identical in nature to Alzheimer’s disease. Data indicate that amyloid and tau protein, derived from brain tissue and blood due to increased permeability of the blood–brain barrier after ischemia, play a key role in post-ischemic neurodegeneration of the hippocampus, with concomitant development of full-blown dementia. Thus, the knowledge of new neurodegenerative mechanisms that cause neurodegeneration of the hippocampus after ischemia, resembling Alzheimer’s disease proteinopathy, will provide the most important therapeutic development goals to date. MDPI 2021-12-28 /pmc/articles/PMC8745293/ /pubmed/35008731 http://dx.doi.org/10.3390/ijms23010306 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pluta, Ryszard
Januszewski, Sławomir
Czuczwar, Stanisław J.
Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer’s Disease Proteinopathy
title Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer’s Disease Proteinopathy
title_full Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer’s Disease Proteinopathy
title_fullStr Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer’s Disease Proteinopathy
title_full_unstemmed Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer’s Disease Proteinopathy
title_short Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer’s Disease Proteinopathy
title_sort post-ischemic neurodegeneration of the hippocampus resembling alzheimer’s disease proteinopathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745293/
https://www.ncbi.nlm.nih.gov/pubmed/35008731
http://dx.doi.org/10.3390/ijms23010306
work_keys_str_mv AT plutaryszard postischemicneurodegenerationofthehippocampusresemblingalzheimersdiseaseproteinopathy
AT januszewskisławomir postischemicneurodegenerationofthehippocampusresemblingalzheimersdiseaseproteinopathy
AT czuczwarstanisławj postischemicneurodegenerationofthehippocampusresemblingalzheimersdiseaseproteinopathy