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The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice

GPR37 is an orphan G-protein-coupled receptor, a substrate of parkin which is linked to Parkinson’s disease (PD) and affective disorders. In this study, we sought to address the effects of early life stress (ELS) by employing the paradigm of limited nesting material on emotional behaviors in adult G...

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Autores principales: Veenit, Vandana, Zhang, Xiaoqun, Ambrosini, Antonio, Sousa, Vasco, Svenningsson, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745300/
https://www.ncbi.nlm.nih.gov/pubmed/35008836
http://dx.doi.org/10.3390/ijms23010410
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author Veenit, Vandana
Zhang, Xiaoqun
Ambrosini, Antonio
Sousa, Vasco
Svenningsson, Per
author_facet Veenit, Vandana
Zhang, Xiaoqun
Ambrosini, Antonio
Sousa, Vasco
Svenningsson, Per
author_sort Veenit, Vandana
collection PubMed
description GPR37 is an orphan G-protein-coupled receptor, a substrate of parkin which is linked to Parkinson’s disease (PD) and affective disorders. In this study, we sought to address the effects of early life stress (ELS) by employing the paradigm of limited nesting material on emotional behaviors in adult GPR37 knockout (KO) mice. Our results showed that, while there was an adverse effect of ELS on various domains of emotional behaviors in wild type (WT) mice in a sex specific manner (anxiety in females, depression and context-dependent fear memory in males), GPR37KO mice subjected to ELS exhibited less deteriorated emotional behaviors. GPR37KO female mice under ELS conditions displayed reduced anxiety compared to WT mice. This was paralleled by lower plasma corticosterone in GPR37KO females and a lower increase in P-T286-CaMKII by ELS in the amygdala. GPR37KO male mice, under ELS conditions, showed better retention of hippocampal-dependent emotional processing in the passive avoidance behavioral task. GPR37KO male mice showed increased immobility in the forced swim task and increased P-T286-CaMKII in the ventral hippocampus under baseline conditions. Taken together, our data showed overall long-term effects of ELS—deleterious or beneficial depending on the genotype, sex of the mice and the emotional context.
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spelling pubmed-87453002022-01-11 The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice Veenit, Vandana Zhang, Xiaoqun Ambrosini, Antonio Sousa, Vasco Svenningsson, Per Int J Mol Sci Article GPR37 is an orphan G-protein-coupled receptor, a substrate of parkin which is linked to Parkinson’s disease (PD) and affective disorders. In this study, we sought to address the effects of early life stress (ELS) by employing the paradigm of limited nesting material on emotional behaviors in adult GPR37 knockout (KO) mice. Our results showed that, while there was an adverse effect of ELS on various domains of emotional behaviors in wild type (WT) mice in a sex specific manner (anxiety in females, depression and context-dependent fear memory in males), GPR37KO mice subjected to ELS exhibited less deteriorated emotional behaviors. GPR37KO female mice under ELS conditions displayed reduced anxiety compared to WT mice. This was paralleled by lower plasma corticosterone in GPR37KO females and a lower increase in P-T286-CaMKII by ELS in the amygdala. GPR37KO male mice, under ELS conditions, showed better retention of hippocampal-dependent emotional processing in the passive avoidance behavioral task. GPR37KO male mice showed increased immobility in the forced swim task and increased P-T286-CaMKII in the ventral hippocampus under baseline conditions. Taken together, our data showed overall long-term effects of ELS—deleterious or beneficial depending on the genotype, sex of the mice and the emotional context. MDPI 2021-12-30 /pmc/articles/PMC8745300/ /pubmed/35008836 http://dx.doi.org/10.3390/ijms23010410 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Veenit, Vandana
Zhang, Xiaoqun
Ambrosini, Antonio
Sousa, Vasco
Svenningsson, Per
The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice
title The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice
title_full The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice
title_fullStr The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice
title_full_unstemmed The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice
title_short The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice
title_sort effect of early life stress on emotional behaviors in gpr37ko mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745300/
https://www.ncbi.nlm.nih.gov/pubmed/35008836
http://dx.doi.org/10.3390/ijms23010410
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