Aromatic Sulfonamides including a Sulfonic Acid Tail: New Membrane Impermeant Carbonic Anhydrase Inhibitors for Targeting Selectively the Cancer-Associated Isoforms

We report here a new drug design strategy for producing membrane-impermeant carbonic anhydrase (CA; EC 4.2.1.1) inhibitors selectively targeting the tumor-associated, membrane-bound human CAs IX and XII over off-target cytosolic isoforms. To date, this approach has only been pursued by including per...

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Detalles Bibliográficos
Autores principales: Giovannuzzi, Simone, D’Ambrosio, Mario, Luceri, Cristina, Osman, Sameh Mohamed, Pallecchi, Marco, Bartolucci, Gianluca, Nocentini, Alessio, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745330/
https://www.ncbi.nlm.nih.gov/pubmed/35008884
http://dx.doi.org/10.3390/ijms23010461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745330/
https://www.ncbi.nlm.nih.gov/pubmed/35008884
http://dx.doi.org/10.3390/ijms23010461

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