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Mechanisms of Melatonin in Obesity: A Review
Obesity and its complications have become a prominent global public health problem that severely threatens human health. Melatonin, originally known as an effective antioxidant, is an endogenous hormone found throughout the body that serves various physiological functions. In recent decades, increas...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745381/ https://www.ncbi.nlm.nih.gov/pubmed/35008644 http://dx.doi.org/10.3390/ijms23010218 |
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author | Guan, Qingyun Wang, Zixu Cao, Jing Dong, Yulan Chen, Yaoxing |
author_facet | Guan, Qingyun Wang, Zixu Cao, Jing Dong, Yulan Chen, Yaoxing |
author_sort | Guan, Qingyun |
collection | PubMed |
description | Obesity and its complications have become a prominent global public health problem that severely threatens human health. Melatonin, originally known as an effective antioxidant, is an endogenous hormone found throughout the body that serves various physiological functions. In recent decades, increasing attention has been paid to its unique function in regulating energy metabolism, especially in glucose and lipid metabolism. Accumulating evidence has established the relationship between melatonin and obesity; nevertheless, not all preclinical and clinical evidence indicates the anti-obesity effect of melatonin, which makes it remain to conclude the clinical effect of melatonin in the fight against obesity. In this review, we have summarized the current knowledge of melatonin in regulating obesity-related symptoms, with emphasis on its underlying mechanisms. The role of melatonin in regulating the lipid profile, adipose tissue, oxidative stress, and inflammation, as well as the interactions of melatonin with the circadian rhythm, gut microbiota, sleep disorder, as well as the α7nAChR, the opioidergic system, and exosomes, make melatonin a promising agent to open new avenues in the intervention of obesity. |
format | Online Article Text |
id | pubmed-8745381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87453812022-01-11 Mechanisms of Melatonin in Obesity: A Review Guan, Qingyun Wang, Zixu Cao, Jing Dong, Yulan Chen, Yaoxing Int J Mol Sci Review Obesity and its complications have become a prominent global public health problem that severely threatens human health. Melatonin, originally known as an effective antioxidant, is an endogenous hormone found throughout the body that serves various physiological functions. In recent decades, increasing attention has been paid to its unique function in regulating energy metabolism, especially in glucose and lipid metabolism. Accumulating evidence has established the relationship between melatonin and obesity; nevertheless, not all preclinical and clinical evidence indicates the anti-obesity effect of melatonin, which makes it remain to conclude the clinical effect of melatonin in the fight against obesity. In this review, we have summarized the current knowledge of melatonin in regulating obesity-related symptoms, with emphasis on its underlying mechanisms. The role of melatonin in regulating the lipid profile, adipose tissue, oxidative stress, and inflammation, as well as the interactions of melatonin with the circadian rhythm, gut microbiota, sleep disorder, as well as the α7nAChR, the opioidergic system, and exosomes, make melatonin a promising agent to open new avenues in the intervention of obesity. MDPI 2021-12-25 /pmc/articles/PMC8745381/ /pubmed/35008644 http://dx.doi.org/10.3390/ijms23010218 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Guan, Qingyun Wang, Zixu Cao, Jing Dong, Yulan Chen, Yaoxing Mechanisms of Melatonin in Obesity: A Review |
title | Mechanisms of Melatonin in Obesity: A Review |
title_full | Mechanisms of Melatonin in Obesity: A Review |
title_fullStr | Mechanisms of Melatonin in Obesity: A Review |
title_full_unstemmed | Mechanisms of Melatonin in Obesity: A Review |
title_short | Mechanisms of Melatonin in Obesity: A Review |
title_sort | mechanisms of melatonin in obesity: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745381/ https://www.ncbi.nlm.nih.gov/pubmed/35008644 http://dx.doi.org/10.3390/ijms23010218 |
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