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The Application of Nanoparticles in Diagnosis and Treatment of Kidney Diseases

Nanomedicine is currently showing great promise for new methods of diagnosing and treating many diseases, particularly in kidney disease and transplantation. The unique properties of nanoparticles arise from the diversity of size effects, used to design targeted nanoparticles for specific cells or t...

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Autores principales: Paluszkiewicz, Patrycja, Martuszewski, Adrian, Zaręba, Natalia, Wala, Kamila, Banasik, Mirosław, Kepinska, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745391/
https://www.ncbi.nlm.nih.gov/pubmed/35008556
http://dx.doi.org/10.3390/ijms23010131
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author Paluszkiewicz, Patrycja
Martuszewski, Adrian
Zaręba, Natalia
Wala, Kamila
Banasik, Mirosław
Kepinska, Marta
author_facet Paluszkiewicz, Patrycja
Martuszewski, Adrian
Zaręba, Natalia
Wala, Kamila
Banasik, Mirosław
Kepinska, Marta
author_sort Paluszkiewicz, Patrycja
collection PubMed
description Nanomedicine is currently showing great promise for new methods of diagnosing and treating many diseases, particularly in kidney disease and transplantation. The unique properties of nanoparticles arise from the diversity of size effects, used to design targeted nanoparticles for specific cells or tissues, taking renal clearance and tubular secretion mechanisms into account. The design of surface particles on nanoparticles offers a wide range of possibilities, among which antibodies play an important role. Nanoparticles find applications in encapsulated drug delivery systems containing immunosuppressants and other drugs, in imaging, gene therapies and many other branches of medicine. They have the potential to revolutionize kidney transplantation by reducing and preventing ischemia–reperfusion injury, more efficiently delivering drugs to the graft site while avoiding systemic effects, accurately localizing and visualising the diseased site and enabling continuous monitoring of graft function. So far, there are known nanoparticles with no toxic effects on human tissue, although further studies are still needed to confirm their safety.
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spelling pubmed-87453912022-01-11 The Application of Nanoparticles in Diagnosis and Treatment of Kidney Diseases Paluszkiewicz, Patrycja Martuszewski, Adrian Zaręba, Natalia Wala, Kamila Banasik, Mirosław Kepinska, Marta Int J Mol Sci Review Nanomedicine is currently showing great promise for new methods of diagnosing and treating many diseases, particularly in kidney disease and transplantation. The unique properties of nanoparticles arise from the diversity of size effects, used to design targeted nanoparticles for specific cells or tissues, taking renal clearance and tubular secretion mechanisms into account. The design of surface particles on nanoparticles offers a wide range of possibilities, among which antibodies play an important role. Nanoparticles find applications in encapsulated drug delivery systems containing immunosuppressants and other drugs, in imaging, gene therapies and many other branches of medicine. They have the potential to revolutionize kidney transplantation by reducing and preventing ischemia–reperfusion injury, more efficiently delivering drugs to the graft site while avoiding systemic effects, accurately localizing and visualising the diseased site and enabling continuous monitoring of graft function. So far, there are known nanoparticles with no toxic effects on human tissue, although further studies are still needed to confirm their safety. MDPI 2021-12-23 /pmc/articles/PMC8745391/ /pubmed/35008556 http://dx.doi.org/10.3390/ijms23010131 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Paluszkiewicz, Patrycja
Martuszewski, Adrian
Zaręba, Natalia
Wala, Kamila
Banasik, Mirosław
Kepinska, Marta
The Application of Nanoparticles in Diagnosis and Treatment of Kidney Diseases
title The Application of Nanoparticles in Diagnosis and Treatment of Kidney Diseases
title_full The Application of Nanoparticles in Diagnosis and Treatment of Kidney Diseases
title_fullStr The Application of Nanoparticles in Diagnosis and Treatment of Kidney Diseases
title_full_unstemmed The Application of Nanoparticles in Diagnosis and Treatment of Kidney Diseases
title_short The Application of Nanoparticles in Diagnosis and Treatment of Kidney Diseases
title_sort application of nanoparticles in diagnosis and treatment of kidney diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745391/
https://www.ncbi.nlm.nih.gov/pubmed/35008556
http://dx.doi.org/10.3390/ijms23010131
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