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Overview of the Development and Use of Akt Inhibitors in Prostate Cancer

Deregulation of the PI3K-Akt-mTOR pathway plays a critical role in the development and progression of many cancers. In prostate cancer, evidence suggests that it is mainly driven by PTEN loss of function. For many years, the development of selective Akt inhibitors has been challenging. In recent pha...

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Detalles Bibliográficos
Autores principales:	Gasmi, Anis, Roubaud, Guilhem, Dariane, Charles, Barret, Eric, Beauval, Jean-Baptiste, Brureau, Laurent, Créhange, Gilles, Fiard, Gaëlle, Fromont, Gaëlle, Gauthé, Mathieu, Ruffion, Alain, Renard-Penna, Raphaële, Sargos, Paul, Rouprêt, Morgan, Ploussard, Guillaume, Mathieu, Romain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745410/ https://www.ncbi.nlm.nih.gov/pubmed/35011901 http://dx.doi.org/10.3390/jcm11010160

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