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Specific Mutations in Aph1 Cause γ-Secretase Activation

Amyloid beta peptides (Aβs) are generated from amyloid precursor protein (APP) through multiple cleavage steps mediated by γ-secretase, including endoproteolysis and carboxypeptidase-like trimming. The generation of neurotoxic Aβ42/43 species is enhanced by familial Alzheimer’s disease (FAD) mutatio...

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Detalles Bibliográficos
Autores principales:	Watanabe, Hikari, Yoshida, Chika, Hidaka, Masafumi, Ogawa, Tomohisa, Tomita, Taisuke, Futai, Eugene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745412/ https://www.ncbi.nlm.nih.gov/pubmed/35008932 http://dx.doi.org/10.3390/ijms23010507

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