The Hedgehog Signaling Pathway in Idiopathic Pulmonary Fibrosis: Resurrection Time

The hedgehog (Hh) pathway is a sophisticated conserved cell signaling pathway that plays an essential role in controlling cell specification and proliferation, survival factors, and tissue patterning formation during embryonic development. Hh signal activity does not entirely disappear after develop...

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Detalles Bibliográficos
Autores principales: Effendi, Wiwin Is, Nagano, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745434/
https://www.ncbi.nlm.nih.gov/pubmed/35008597
http://dx.doi.org/10.3390/ijms23010171
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author Effendi, Wiwin Is
Nagano, Tatsuya
author_facet Effendi, Wiwin Is
Nagano, Tatsuya
author_sort Effendi, Wiwin Is
collection PubMed
description The hedgehog (Hh) pathway is a sophisticated conserved cell signaling pathway that plays an essential role in controlling cell specification and proliferation, survival factors, and tissue patterning formation during embryonic development. Hh signal activity does not entirely disappear after development and may be reactivated in adulthood within tissue-injury-associated diseases, including idiopathic pulmonary fibrosis (IPF). The dysregulation of Hh-associated activating transcription factors, genomic abnormalities, and microenvironments is a co-factor that induces the initiation and progression of IPF.
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spelling pubmed-87454342022-01-11 The Hedgehog Signaling Pathway in Idiopathic Pulmonary Fibrosis: Resurrection Time Effendi, Wiwin Is Nagano, Tatsuya Int J Mol Sci Review The hedgehog (Hh) pathway is a sophisticated conserved cell signaling pathway that plays an essential role in controlling cell specification and proliferation, survival factors, and tissue patterning formation during embryonic development. Hh signal activity does not entirely disappear after development and may be reactivated in adulthood within tissue-injury-associated diseases, including idiopathic pulmonary fibrosis (IPF). The dysregulation of Hh-associated activating transcription factors, genomic abnormalities, and microenvironments is a co-factor that induces the initiation and progression of IPF. MDPI 2021-12-24 /pmc/articles/PMC8745434/ /pubmed/35008597 http://dx.doi.org/10.3390/ijms23010171 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Effendi, Wiwin Is
Nagano, Tatsuya
The Hedgehog Signaling Pathway in Idiopathic Pulmonary Fibrosis: Resurrection Time
title The Hedgehog Signaling Pathway in Idiopathic Pulmonary Fibrosis: Resurrection Time
title_full The Hedgehog Signaling Pathway in Idiopathic Pulmonary Fibrosis: Resurrection Time
title_fullStr The Hedgehog Signaling Pathway in Idiopathic Pulmonary Fibrosis: Resurrection Time
title_full_unstemmed The Hedgehog Signaling Pathway in Idiopathic Pulmonary Fibrosis: Resurrection Time
title_short The Hedgehog Signaling Pathway in Idiopathic Pulmonary Fibrosis: Resurrection Time
title_sort hedgehog signaling pathway in idiopathic pulmonary fibrosis: resurrection time
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745434/
https://www.ncbi.nlm.nih.gov/pubmed/35008597
http://dx.doi.org/10.3390/ijms23010171
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